Polyurethanes for osteoimplants
AssigneeWarsaw Orthopedic, Inc.
InventorsDavid Knaack, John Winterbottom, David Kaes, Todd Boyce, Larry Shimp
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Abstract
Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
Claims35
A polyurethane composite, comprising:
- a polyurethane formed by reaction of a polyisocyanate with a hydroxylated or aminated material to form a polyurethane polymer, wherein the composite comprises an included material comprising a biomolecule, extracellular matrix component, bioactive agent, small molecule, tissue-derived material, inorganic ceramic, bone substitute, modified forms of the above, or a mixture of any of the above.
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A biodegradable polyurethane, formed by reaction of a polyisocyanate with optionally hydroxylated biomolecules to form a polyurethane polymer, wherein the optionally hydroxylated biomolecules comprise one or more of polysaccharides and starches and one or more of lipids and phospholipids.
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A non-biodegradable polyurethane, formed by reaction of a polyisocyanate with optionally hydroxylated biomolecules to form a polyurethane polymer, wherein the optionally hydroxylated biomolecules comprise one or more of polysaccharides and starches.
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A method of making a polyurethane composite, comprising:
- reacting a polyisocyanate with a hydroxylated or aminated material in the presence of an included material to form a polyurethane polymer matrix having particles of said included material embedded therein,
- wherein said included material comprises a biomolecule, extracellular matrix component, bioactive agent, small molecule, tissue-derived material, inorganic ceramic, bone substitute, modified forms of the above, or a mixture of any of the above.
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Dependencies are inferred from the claim text.