Cockroach allergen gene expression and delivery systems and uses
OwnerTai Yooinventor
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Abstract
The invention relates to compositions and methods for managing cockroach allergies in mammals. In particular aspects, the invention relates to the administration to a mammal of nucleic acids that encode a cockroach allergen. The compositions are prepared and administered in such a manner that the cockroach allergen coding sequence is expressed in the mammal to which the composition is administered. The compositions include expression systems, delivery systems, and certain cockroach allergens coding sequences.
Claims25
A method of treating or prophylaxis of an allergen in a mammal, said method comprising administering to said mammal a polynucleotide comprising a sequence encoding a cockroach allergen or a fragment thereof.
A method for generating an immune response in a mammal, said method comprising administering to said mammal a polynucleotide comprising a sequence encoding a cockroach allergen or a fragment thereof.
A composition comprising a polynucleotide comprising a sequence encoding a cockroach allergen or fragment thereof and a pharmaceutically acceptable carrier.
A method of preparing a composition for expression of a cockroach allergen or fragment thereof in a mammal, said method comprising preparing a polynucleotide comprising a promoter enhancer transcriptionally linked to a sequence encoding a cockroach allergen or a fragment thereof;
- preparing a transfection facilitating material;
- and combining said transfection facilitating material with said polynucleotide.
A method for detecting sensitivity to a cockroach allergen in an individual, said method comprising administering a polynucleotide comprising a sequence encoding a cockroach allergen or a fragment thereof to the individual and determining an allergic response.
Dependencies are inferred from the claim text.