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US 2006/0216310 A1Published application
Methods of treating and detecting cancer using viruses
AssigneeWellstat Biologics Corporation
InventorsRobert Lorence, Kirk Reichard
Life of this patent
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AssigneeWellstat Biologics Corporation
InventorsRobert Lorence, Kirk Reichard
Estimating the term…
The invention provides a method of treating cancer in a mammal comprising administering to the mammal an effective amount of virus, particularly Newcastle Disease Virus or other Paramyxovirus. The invention also provides a method of treating cancer in a mammal comprising administering such viruses to the mammal in combination with another agent such as a chemotherapeutic compound, immunoadjuvant, cytokine, or immunosuppressive agent. The invention further provides a method of detecting cancer cells in a mammal using Paramyxovirus as an imaging agent and as an indicator of cancer cell growth in the mammal. The invention further provides genetically engineered Paramyxoviruses, and kits containing the viral compositions disclosed by the invention.
1-12. (canceled)
A method of treating cancer in a mammal having a tumor comprising administering intravenously to said mammal more than one dose of a composition comprising live Newcastle Disease Virus in an amount sufficient to cause tumor regression, wherein said composition is essentially free of allantoic fluid.
A method of treating cancer in a mammal having a tumor comprising administering to said mammal more than one dose of a pharmaceutical composition comprising live purified Newcastle Disease Virus in an amount sufficient to cause tumor regression, wherein said live purified Newcastle Disease Virus is administered systemically not directly at the tumor site.
A method of treating cancer in a mammal comprising administering intravenously to said mammal more than one dose of a pharmaceutical composition comprising live purified Newcastle Disease Virus, wherein at the time of said administering step said mammal had already been treated for cancer and the cancer failed to completely respond or recurred.
A method of treating a mammal with a tumor, comprising surgically removing the tumor and administering systemically to said mammal after said tumor removal more than one dose of a composition comprising live Newcastle Disease Virus in an amount sufficient to prevent reoccurrence of said tumor.
A pharmaceutical composition suitable for treating a mammal having a tumor, said composition comprising purified live Newcastle Disease Virus.
A pharmaceutical dose comprising a composition suitable for treating a mammal having a tumor, said composition comprising purified live Newcastle Disease Virus, said composition being present in said dose in an amount sufficient to cause tumor regression when administered to said mammal.
A kit comprising a container containing a pharmaceutical composition suitable for treating a mammal having a tumor, said composition comprising purified live Newcastle Disease Virus, said composition being present in said container in an amount sufficient to cause tumor regression when administered in one or more doses.
Dependencies are inferred from the claim text.