US 2006/0216307 A1 · Vaccine composition

Abstract

The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.

Claims18

Dependent claims

1-111. (canceled)

A genetically-engineered bleb preparation isolated from a modified Neisseria meningitidis strain characterized in that said preparation is obtainable by the following process:

a) a process of reducing immunodominant variable or non-protective antigens within the bleb preparation comprising the steps of engineering said bacterial strain to produce less or none of the PorA antigen, and making blebs from said strain.

Dependencies are inferred from the claim text.

Vaccine composition

Life of this patent

Vaccine composition

Life of this patent

Abstract

Claims18