Plasmodium falciparum antigens inducing protective antibodies
AssigneeInstitut Pasteur
InventorPierre Druilhe
Life of this patent
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Abstract
The invention provides novel preparations for a broad-spectrum antiplasmodial vaccine.
Claims33
A purified polypeptide selected in the group comprising the following peptides:
- MSP3a:
- (SEQ ID No:
- 11)
- 167-YEKAKNAYQKANQAVLKAKEASSYD-191,
- MSP3b:
- (SEQ ID No:
- 12)
- 184-AKEASSYDYILGWEFGGGVPEHKKEEN-210,
- MSP3c:
- (SEQ ID No:
- 13)
- 203-PEHKKEENMLSHLYVSSKDKENISKEND-230,
- MSP3d:
- (SEQ ID No:
- 14)
- 211-MLSHLYVSSKDKENISKENDDVLDEKEEEAEETEEEELEEK-251,
- and combinations thereof.
A long synthetic or recombinant polypeptide comprising epitopes contained within a MSP-3a peptide (SEQ ID No:
- 11), a MSP-3b peptide (SEQ ID No:
- 12), a MSP-3c peptide (SEQ ID No:
- 13), or a MSP-3d peptide (SEQ ID No:
- 14) and combinations of said peptides.
An immunogenic composition comprising as an immunogen a long synthetic or recombinant peptide comprising epitopes contained within a MSP-3b peptide (SEQ ID No:
- 12), a MSP-3c peptide (SEQ ID No:
- 13), or a MSP-3d peptide (SEQ ID No:
- 14) and combinations of said peptides.
A method for in vitro prognosis of the fate of a cerebral malaria patient, comprising measuring the level of anti-MSP-3 IgG3 and/or IgG1 antibodies and the serum of said patient;
- and correlating a low level of said IgG3 and/or IgG1 anti-MSP-3 antibodies with the possibility that the patient may not be saved only by quinine treatment.
A method for treating a cerebral malaria patient in need thereof, comprising administering to said patient anti-MSP-3 IgG3 or IgG1 antibodies.
A method for lowering the parasitemia in a malarial patient in need thereof, comprising administering to said patient anti-MSP-3 IgG3 or IgG1 antibodies or both.
A kit for the in vitro control of a premunition state against malaria in an individual who has been immunized against it, comprising a native MSP-3 protein from Plasmodium falciparum, a medium suitable for formation of an antigen-antibody complex, and reagents for detection of the antigen-antibody complex.
Dependencies are inferred from the claim text.