Method of modulation
OwnerIan McLennan, Kyoko Koishi +1inventors
InventorsIan McLennan, Kyoko Koishi, Pei-Yu Wang
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Abstract
Disclosed are methods for modulating neuron activity, and in particular, for modulating motor neuron function and activity, particularly for use in the treatment, prevention, and/or amelioration of symptoms of one or more motor neuron conditions or diseases in a mammal. Also disclosed are compositions comprising one or more agonists or antagonists of a mammalian Müllerian Inhibitory Substance receptor polypeptide, as well as pharmaceutical formulations, isolated host cells, and therapeutic and/or diagnostic kits that comprises such agonists or antagonists.
Claims20
A method of modulating motor neuron activity in a patient in need thereof, said method comprising at least the step of administering to said patient a therapeutically-effective amount of at least one Müllerian inhibitory substance receptor agonist or antagonist for a time sufficient to modulate said motor neuron activity in said patient.
A method of enhancing neuronal cell survival in-vitro, said method comprising at least the step of culturing a population of neuronal cells in the presence of at least one Müllerian inhibitory substance receptor agonist or antagonist in an amount and for a time sufficient to enhance said neuronal cell survival in vitro.
A pharmaceutical composition comprising at least one Müllerian inhibitory substance receptor agonist or antagonist and a pharmaceutically-acceptable carrier or excipient.
Dependencies are inferred from the claim text.