Glycoprotein VI and uses thereof
AssigneeMillennium Pharmaceuticals, Inc.
InventorsSamantha Busfield, Jean-Luc Villeval, Martine Jandrot-Perrus, William Vainchencker
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AssigneeMillennium Pharmaceuticals, Inc.
InventorsSamantha Busfield, Jean-Luc Villeval, Martine Jandrot-Perrus, William Vainchencker
Estimating the term…
The invention provides isolated nucleic acid molecules and polypeptide molecules that encode glycoprotein VI, a platelet membrane glycoprotein that is involved platelet-collagen interactions. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
An isolated nucleic acid molecule selected from the group consisting of:
An isolated polypeptide selected from the group consisting of:
A method for modulating an activity of a TANG0268 polypeptide in a subject comprising administering an anti-TANG0268 antibody to the subject to thereby modulate an activity of a TANG0268 polypeptide.
A method for treating a subject having a disorder associated with aberrant expression or activity of a TANGO268 polypeptide, comprising administering an anti-TANGO268 antibody to the subject, thereby treating said subject having a disorder associated with aberrant expression or activity of a TANGO0268 polypeptide.
Dependencies are inferred from the claim text.