Myostatin inhibiting fusion polypeptides and therapeutic methods thereof
OwnerDavid Glass, Brian Clarkeinventors
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Abstract
Myostatin inhibiting GDF8 and GDF11 fusion polypeptides and their encoding nucleic acids are disclosed. Pharmaceutical compositions comprising these fusion polypeptides or their corresponding nucleic acids and methods of use are also disclosed.
Claims20
A recombinant nucleic acid molecule encoding a myostatin-inhibiting fusion polypeptide (P)x−M, wherein P is a fragment of growth and differentiation factor (GDF) prodomain GDF8 or GDF11, M is a multimerizing component, and wherein X is a number between 1 and 10.
The nucleic acid molecule of claim 2, wherein P is a fragment of GDF8 or GDF11 selected from the group consisting of SEQ ID NO:
- 3-8 and 27-32.
The nucleic acid molecule of claim 8, wherein the targeting component comprises an N-terminal extracellular domain of muscle cadherin or a MuSK receptor.
A myostatin-inhibiting fusion polypeptide (P)x−M, wherein P is a fragment of a growth and differentiation factor (GDF) prodomain GDF8 or GDF11, M is a multimerizing component, and wherein X is a number between 1 and 10.
Dependencies are inferred from the claim text.