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OwnerBryan Conn, Barry Smith +2inventors
InventorsBryan Conn, Barry Smith, Albert Rubin, Kurt Stenzel
Estimating the term…
The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.
1-18. (canceled)
A method for inhibiting proliferation of at least a portion of a non-entrapped cell population, comprising culturing said cell population in the presence of a composition of matter comprising a sample of stem cells entrapped in a biocompatible, selectively permeable structure, wherein said entrapped stem cells produce a factor which inhibits proliferation of said at least a portion of said non-entrapped cell population.
A method for inhibiting proliferation of at least a portion of a cell population comprising administering the composition of matter of claim 1 to a subject in need thereof, in an amount sufficient and at a site sufficient to inhibit proliferation of at least a portion of said cell population.
A method for inhibiting proliferation of a non-entrapped cell population, comprising culturing a composition of matter comprising a sample of stem cells entrapped in a biocompatible, selectively permeable structure, wherein said entrapped stem cells produce a factor which inhibits proliferation of at least a portion of said non-entrapped cell population, in a medium for a time sufficient to permit diffusion of a cell proliferation inhibiting material into said medium, and contacting said medium to said non-entrapped cell population for a time sufficient to inhibit proliferation of said non-entrapped cell population.
A method for inhibiting proliferation of a non-entrapped population of stem cells, comprising culturing said stem cells in the presence of a composition of matter which comprises a sample of cancer cells entrapped in a biocompatible, selectively permeable structure, wherein said sample of cancer cells produces material which inhibits proliferation of said stem cells.
A method for inhibiting proliferation of non-entrapped stem cells, comprising culturing a composition of matter which comprises a sample of cancer cells entrapped in a biocompatible, selectively permeable structure, wherein said sample of cancer cells produces material which inhibits proliferation of stem cells and which diffuses into a culture medium, and contacting said culture medium to said stem cells.
64-65. (canceled)
A method for inhibiting differentiation of at least a portion of a population of stem cells, comprising entrapping said stem cells in a biocompatible, selectively permeable structure, wherein such entrapment causes at least a portion of said stem cells to remain in an undifferentiated state.
Dependencies are inferred from the claim text.