Insulin-producing bone marrow derived cells and methods of generating and using same
AssigneeRamot at Tel-Aviv University Ltd.
InventorShimon Efrat
Life of this patent
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Abstract
Insulin-producing bone marrow derived stem cells, and methods of generating and using same to reduce blood glucose levels in individuals.
Claims31
1-74. (canceled)
A method of generating insulin-producing cells comprising:
- (a) isolating and optionally culturing adult tissue stem cells to thereby obtain an adult tissue stem cell culture;
- and
- (b) expressing exogenous Pdx1 in cells of said adult tissue stem cell culture to thereby obtain insulin-producing cells.
A cell culture comprising adult tissue stem cells genetically modified to express Pdx 1.
A method of reducing blood glucose levels in an individual comprising administering Pdx1-expressing adult tissue stem cells to the individual thereby reducing blood glucose levels in the individual.
A method of treating an individual having a disorder requiring β-cell replacement, comprising administering Pdx1-expressing adult tissue stem cells to the individual thereby treating the individual.
Dependencies are inferred from the claim text.