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US 2006/0216274 A1Published application
Induction of immune response to antigens expressed by recombinant adeno-associated virus
OwnerGary Kurtzman, Edgar Engelman +2inventors
InventorsGary Kurtzman, Edgar Engelman, Greg Podsakoff, Dirk Brockstedt
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Abstract
The present invention relates generally to immunization methods using recombinant viral vectors. In particular, the invention relates to methods and compositions for immunizing a subject with a nucleic acid molecule encoding an antigen of interest, wherein the nucleic acid molecule is delivered to the subject via a recombinant AAV virion.
Claims4
A method of eliciting an immune response in a mammalian subject comprising:
- providing a recombinant AAV virion containing a nucleic acid molecule encoding at least one acquired immunodeficiency syndrome (AIDS) virus antigen operably linked to control sequences which direct the expression of said AIDS virus antigen in a suitable recipient cell;
- and
- introducing said recombinant AAV virion into a recipient cell of said mammalian subject under conditions that permit the expression of said AIDS virus antigen, wherein the expression of said AIDS virus antigen elicits an immune response to said AIDS virus antigen.
Dependencies are inferred from the claim text.