DNA 19355 polypeptide, a tumor necrosis factor homolog
AssigneeGenentech, Inc.
InventorsAvi Ashkenazi, Kevin Baker, Paul Godowski, Austin Gurney, Melanie Mark, Scot Marsters, Robert Pitti
Life of this patent
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Abstract
A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
Claims22
Isolated nucleic acid comprising DNA encoding DNA19355 polypeptide comprising amino acid residues X to 177 of FIG. 1 (SEQ ID NO:1), wherein X is any one of amino acid residues 48 to 57 of FIG. 1 (SEQ ID NO:1).
Isolated DNA19355 polypeptide comprising amino acid residues 1 to 177 of FIG. 1 (SEQ ID NO:1).
Isolated DNA19355 polypeptide having at least about 80% amino acid sequence identity with native sequence DNA19355 polypeptide comprising amino acid residues 1 to 177 of FIG. 1 (SEQ ID NO:1).
Isolated DNA19355 polypeptide comprising:
- (a) amino acid residues X to 177 of FIG. 1 (SEQ ID NO:1), wherein X is any one of amino acid residues 48 to 57 of FIG. 1 (SEQ ID NO:1);
- or
- (b) a fragment of (a), wherein said fragment is biologically active.
Isolated DNA19355 polypeptide encoded by the cDNA insert of the vector deposited as ATCC 209466.
17-21. (canceled)
An antibody which specifically binds to DNA19355 polypeptide.
A method of inducing apoptosis in mammalian cancer cells comprising exposing mammalian cancer cells to an effective amount of DNA19355 polypeptide.
A method of stimulating a proinflammatory response in mammalian cells, comprising exposing said mammalian cells to an effective amount of DNA19355 polypeptide.
Dependencies are inferred from the claim text.