Delivery of compounds for the treatment of parkinson's through an inhalation route

A composition for delivery of pergolide consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of pergolide on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of pergolide and condensing the heated vapor of pergolide to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% pergolide degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of amantadine consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of amantadine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of amantadine and condensing the heated vapor of amantadine to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% amantadine degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of deprenyl consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of deprenyl on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of deprenyl and condensing the heated vapor of deprenyl to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% deprenyl degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of ropinerole consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of ropinerole on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of ropinerole and condensing the heated vapor of ropinerole to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% ropinerole degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A method of producing benzotropine in an aerosol form comprising:

• a. heating a thin layer of benzotropine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the benzotropine to form a heated vapor of the benzotropine, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the benzotropine comprising less than 5% benzotropine degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing pergolide in an aerosol form comprising:

• a. heating a thin layer of pergolide on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the pergolide to form a heated vapor of the pergolide, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the pergolide comprising less than 5% pergolide degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing amantadine in an aerosol form comprising:

• a. heating a thin layer of amantadine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the amantadine to form a heated vapor of the amantadine, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the amantadine comprising less than 5% amantadine degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing deprenyl in an aerosol form comprising:

• a. heating a thin layer of deprenyl on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the deprenyl to form a heated vapor of the deprenyl, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the deprenyl comprising less than 5% deprenyl degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing ropinerole in an aerosol form comprising:

• a. heating a thin layer of ropinerole on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the ropinerole to form a heated vapor of the ropinerole, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the ropinerole comprising less than 5% ropinerole degradation products, and an aerosol having an MMAD of less than 3 microns.