Delivery of Beta-Blockers Through An Inhalation Route

A composition for delivery of pindolol consisting of a condensation aerosol a) formed by volatilizing a thin layer of pindolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of pindolol and condensing the heated vapor of pindolol to form condensation aerosol particles,

• b) wherein said condensation aerosol particles are characterized by less than 5% pindolol degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of esmolol consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of esmolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of esmolol and condensing the heated vapor of esmolol to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% esmolol degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of propranolol consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of propranolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of propranolol and condensing the heated vapor of propranolol to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% propranolol degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A composition for delivery of propranolol consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of propranolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of propranolol and condensing the heated vapor of propranolol to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% propranolol degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A method of producing atenolol in an aerosol form comprising:

• a. heating a thin layer of atenolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the atenolol to form a heated vapor of the atenolol, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the atenolol comprising less than 5% atenolol degradation products, and an aerosol having an MMAD of less than 3 microns.

The method according to claim 17, wherein the aerosol particles are formed at a rate of greater than 109 particles per second.

The method according to claim 18, wherein the aerosol particles are formed at a rate of greater than 1010 particles per second

A method of producing pindolol in an aerosol form comprising:

• a. heating a thin layer of pindolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the pindolol to form a heated vapor of the pindolol, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the pindolol comprising less than 5% pindolol degradation products, and an aerosol having an MMAD of less than 3 microns.

The method according to claim 20, wherein the aerosol particles are formed at a rate of greater than 109 particles per second.

The method according to claim 21, wherein the aerosol particles are formed at a rate of greater than 1010 particles per second.

A method of producing esmolol in an aerosol form comprising:

• a. heating a thin layer of esmolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the esmolol to form a heated vapor of the esmolol, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the esmolol comprising less than 5% esmolol degradation products, and an aerosol having an MMAD of less than 3 microns.

The method according to claim 23, wherein the aerosol particles are formed at a rate of greater than 109 particles per second.

The method according to claim 24, wherein the aerosol particles are formed at a rate of greater than 1010 particles per second.

A method of producing propranolol in an aerosol form comprising:

• a. heating a thin layer of propranolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the propranolol to form a heated vapor of the propranolol, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the propranolol comprising less than 5% propranolol degradation products, and an aerosol having an MMAD of less than 3 microns.

The method according to claim 26, wherein the aerosol particles are formed at a rate of greater than 109 particles per second.

The method according to claim 27, wherein the aerosol particles are formed at a rate of greater than 1010 particles per second.

A method of producing metoprolol in an aerosol form comprising:

• a. heating a thin layer of metoprolol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the metoprolol to form a heated vapor of the metoprolol, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the metoprolol comprising less than 5% metoprolol degradation products, and an aerosol having an MMAD of less than 3 microns.