Buccal, polar and non-polar spray containing zolpidem
AssigneeNovaDel Pharma, Inc.
InventorsHarry Dugger, Mohammed Abd El-Shafy
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AssigneeNovaDel Pharma, Inc.
InventorsHarry Dugger, Mohammed Abd El-Shafy
Estimating the term…
Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, zolpidem, and optional flavoring agent; formulation II: aqueous polar solvent, zolpidem, optionally flavoring agent, and propellant; formulation III: non-polar solvent, zolpidem, and optional flavoring agent; formulation IV: non-polar solvent, zolpidem, optional flavoring agent, and propellant; formulation V: a mixture of a polar solvent and a non-polar solvent, zolpidem, and optional flavoring agent; formulation VI: a mixture of a polar solvent and a non-polar solvent, zolpidem, optional flavoring agent, and propellant.
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An oral spray composition for transmucosal administration of zolpidem or a pharmaceutically acceptable salt thereof comprising:
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An oral spray composition for transmucosal administration of zolpidem or a pharmaceutically acceptable salt thereof comprising:
An oral spray composition for transmucosal administration of zolpidem or a pharmaceutically acceptable salt thereof comprising:
An oral spray composition for transmucosal administration of zolpidem or a pharmaceutically acceptable salt thereof comprising:
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An oral spray composition for transmucosal administration of zolpidem or a pharmaceutically acceptable salt thereof comprising:
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Dependencies are inferred from the claim text.