Magnetic nanoparticle compositions and methods
AssigneeWashington University
InventorsMiqin Zhang, Nathan Kohler, Jonathan Gunn
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Abstract
A nanoparticle having a core comprising a magnetic material and surface to which are covalently coupled a plurality of silane moieties, wherein each silane moiety comprises a polyalkylene oxide moiety. The nanoparticle can further include a targeting agent, a targeting agent and a diagnostic agent, or a targeting agent and a therapeutic agent. Methods for using the nanoparticle to detect and treat tissues of interest.
Claims31
A compound having the formula:
- wherein,
- R1 is selected from the group consisting of alkyl and aryl;
- R2 is selected from the group consisting of alkyl and aryl;
- n is 1, 2, 3, 4, 5, or 6;
- and
- m is an integer from about 10 to about 1000.
A particle, comprising:
- (a) a core having a surface;
- and
- (b) a plurality of silane moieties, wherein the silane moiety is covalently coupled to the surface, and wherein the silane moiety has the formula:
- wherein,
- R2 is selected from the group consisting of alkyl and aryl;
- n is 1, 2, 3, 4, 5, o r6;
- and
- m is an integer from about 10 to about 1000.
A nanoparticle, comprising:
- (a) a core comprising a magnetic material and having a surface;
- and
- (b) a plurality of silane moieties, wherein each silane moiety is covalently coupled to the surface, and wherein the silane moiety has the formula:
- wherein,
- R2 is selected from the group consisting of alkyl and aryl;
- n is 1, 2, 3, 4, 5, or 6;
- and
- m is an integer from about 10 to about 1000.
A nanoparticle, comprising:
- (a) a core comprising a magnetic material and having a surface;
- and
- (b) a plurality of silane moieties, wherein each silane moiety is covalently coupled to the surface, wherein at least a portion of the plurality of silane moieties comprises a targeting agent, and wherein the silane moieties comprise a polyalkylene oxide moiety intermediate the surface and the targeting agent.
A nanoparticle, comprising:
- (a) a core comprising a magnetic material and having a surface;
- and
- (b) a plurality of silane moieties, wherein each silane moiety is covalently coupled to the core, and wherein the silane moiety has the formula:
- wherein,
- n is 1, 2, 3, 4, 5, or 6;
- m is an integer from about 10 to about 1000;
- L is a direct bond or a linker;
- and
- T is a targeting agent.
A method for detecting cells or tissues by magnetic resonance imaging, comprising:
- (a) contacting cells or tissues of interest with a nanoparticle having affinity and specificity for the cells or tissues of interest, wherein the nanoparticle comprises
- (i) a core comprising a magnetic material and having a surface, and
- (ii) a plurality of silane moieties,
- wherein each silane moiety is covalently coupled to the surface,
- wherein the silane moiety comprises a targeting moiety having affinity and specificity to the cells or tissues of interest, and
- wherein the silane moiety comprises a polyalkylene oxide moiety intermediate the core and the targeting agent;
- and
- (b) measuring the level of binding of the nanoparticle, wherein an elevated level of binding, relative to normal cells or tissues, is indicative of binding to the cells or tissues of interest.
A method for treating a tissue, comprising contacting a tissue of interest with a nanoparticle having affinity and specificity for the tissue of interest, wherein the nanoparticle comprises
- (a) a core comprising a magnetic material and having a surface, and
- (b) a plurality of silane moieties,
- wherein each silane moiety is covalently coupled to the surface,
- wherein at least a portion of the plurality of silane moieties comprise a targeting moiety having affinity and specificity to the tissue of interest,
- wherein at least a portion of the plurality of silane moieties comprise a therapeutic agent,
- wherein each silane moiety comprising a targeting agent comprises a polyalkylene oxide moiety intermediate the core and the targeting agent;
- and
- wherein each silane moiety comprising a therapeutic agent comprises a polyalkylene oxide moiety intermediate the core and the therapeutic agent.
Dependencies are inferred from the claim text.