Compositions and methods for targeting or imaging a tissue in a vertebrate subject
OwnerMarianne Manchester, Heidi Stuhlmann +6inventors
InventorsMarianne Manchester, Heidi Stuhlmann, John Lewis, Giuseppe Destito, John Johnson, Anju Chatterjee, Pratik Singh, Maria Gonzalez
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Abstract
Compositions and methods are provided for targeting or imaging to a tumor or organ in a vertebrate subject. A plant viral particle for targeting and imaging and methods for treatment of disease are also provided.
Claims140
A method for targeting or imaging a tissue in a vertebrate subject comprising
- administering to the vertebrate subject a plant viral particle comprising a plurality of targeting/imaging molecules covalently attached to the viral particle, and
- delivering the targeting/imaging molecules on the viral particle to the tissue in the vertebrate subject.
A method for treating or preventing a disease in a vertebrate subject comprising, administering to the vertebrate subject a plant viral particle comprising a plurality of targeting/imaging molecules directed to a tissue of the vertebrate subject, wherein the targeting/imaging molecule binds to the tissue to treat or prevent the disease of the vertebrate subject.
A plant viral particle comprising:
- a viral subunit comprising a plurality of covalent attachment sites,
- a plurality of targeting/imaging molecules covalently attached to the viral subunit, and
- a plurality of viral subunits assembled into the viral particle displaying the plurality of targeting/imaging molecules on the viral particle.
Dependencies are inferred from the claim text.