Methods for diagnosing and treating tumors and suppressing cd promoters
OwnerCarl Shelley, Omid Farokhzadinventors
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Abstract
Methods of treating tumors, reducing white blood cell numbers, and inhibiting CD promoters are provided.
Claims30
A method for characterizing an ovarian cell, the method comprising:
- determining the presence or absence of a CD43 molecule in an ovarian cell of a subject to characterize the ovarian cell.
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A method of treating a subject having or at risk of having a tumor, comprising:
- administering to a subject in need of such treatment one or more CD43 inhibitors in an effective amount to treat the tumor.
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A method for assessing the regression or progression of an ovarian tumor in a subject with comprising the steps of:
- measuring in a first ovarian cell obtained from the subject, the presence of a CD43 molecule,
- measuring in a second ovarian cell obtained from the subject, the presence of a CD43 molecule,
- comparing the presence of the CD43 molecule in the first ovarian cell and the second ovarian cell,
- wherein a decrease in the presence of the CD43 molecule in the second ovarian cell compared to the first ovarian cell indicates regression of the ovarian tumor, and
- wherein an increase in the presence of the CD43 molecule in the second ovarian cell compared to the first ovarian cell indicates progression of the ovarian tumor.
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A kit for diagnosing an ovarian tumor, comprising:
- one or more CD43 binding molecules,
- one or more control agents, and
- instructions for the use of the CD43 binding molecules, and the control agents in the diagnosis of an ovarian tumor.
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A method of reducing the number of white blood cells in a subject comprising administering to a subject in need of a reduction in the number of white blood cells, a CD43 inhibitor in an effective amount to reduce the number of white blood cells in said subject.
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A method of inhibiting a CD promoter comprising contacting the CD promoter with a CD43 inhibitor in an amount effective to inhibit the CD promoter.
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Dependencies are inferred from the claim text.