Fluidically isolated pumping and metered fluid delivery system and methods
OwnerPaul Lum, Ganapati Mauze +1inventors
InventorsPaul Lum, Ganapati Mauze, Catherine Templin
Life of this patent
Estimating the term…
Abstract
An apparatus and method for pumping and optionally mixing of small quantities of biological fluid wherein the pumping mechanism is segregated from the biological fluid being pumped. The micro-pump pushes the biological fluid by compressing a cartridge housing the blood and reagents with collapsible walls with a roller or ball bearing, synchronized perpendicular plungers, or an acutely-angled member to push the biological fluid by collapsing the walls of the cartridge in the direction of flow.
Claims21
1-11. (canceled)
A micro pumping device for transporting biological fluid comprising:
- a first reservoir for containing at least one first biological fluid, said first reservoir comprising a deformable material;
- a second reservoir for containing a second biological fluid;
- said second reservoir comprising a deformable material;
- a mixing chamber to collect a mixture of the first and second biological fluids;
- said chamber connected to said first reservoir and said second reservoir through a channel, said channel forking into a first leg and a second leg, said first leg connected to said first reservoir, and said second leg connected to said second reservoir, said mixing chamber and said channel comprising a deformable material;
- and
- a means for collapsing said first reservoir, said second reservoir, and said channel.
A method of micro pumping biological fluid comprising:
- collapsing a cartridge matrix comprising at least one pliable surface and at least one reservoir and channel, wherein said collapsing is adapted to transport biological fluid contained within said reservoir.
An analytical instrument comprising:
- a cartridge adapted to receive at least one biological fluid, said cartridge comprising an analytical system chosen from electrochemical, chemiluminescence, optical, electrical, and mechanical methods, wherein said cartridge comprises a pliable surface;
- and
- a collapsor adapted to transporting small volumes of biological fluid for said analytical system by collapsing said pliable surface with a compression force.
The analytical instrument of 16 wherein:
- said collapsor comprises a unitary member.
The analytical instrument of 17, wherein said collapsor includes a collapsor surface with protrusions having predetermined spacing, said predetermined spacing creating corresponding concavities in said pliable surface as said collapsor collapses said pliable surface against a rigid core, displacement from said corresponding concavities thereby causing a predetermined amount of biological fluid to be delivered from the cartridge.
The analytical instrument of 30, further comprising a bearing, wherein said collapsor surface comprises a circumference of said bearing;
- said protrusions disposed at predetermined locations about said circumference such that each adjacent pair of protrusions defines a correspondingly predetermined volume.
Dependencies are inferred from the claim text.