Wet milling process
AssigneeSmithKlineBeecham Corporation
InventorsSimon Holland, Wendy Knight, Graham Leonard
Life of this patent
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Abstract
A process for preparing a finely divided preparation of a drug substance comprising wet milling a suspension of the drug substance in a mill having at least one chamber and agitation means, said chamber(s) and/or said agitation means comprising nylon, wherein the nylon comprises one or more internal lubricants results in finely divided preparations of a drug substance in which the level of grinding media contamination and process contamination are reduced.
Claims17
Process for preparing a finely divided preparation of a drug substance comprising wet milling a suspension of the drug substance in a mill having at least one chamber and agitation means, said chamber(s) and/or said agitation means comprising lubricated nylon.
The process as claimed in any preceding claim wherein the lubricated nylon comprises one or more liquid lubricants.
The process as claimed in any preceding claim wherein the lubricated nylon comprises more than one lubricant.
The process according to any preceding claim wherein the lubricated nylon has a coefficient of friction of ≦0.35.
The process as claimed in any preceding claim wherein the lubricated nylon is Nylube™, Oilon™, or Nyloil-FG™.
The process according to any one of the preceding claims which further comprises the step of drying the drug substance.
Dependencies are inferred from the claim text.