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US 2006/0213836 A1Published application
Ultrafiltration membrane,device, bioartificial organ, and methods
AssigneesThe Regents of the University of Michigan, The Cleveland Clinic Foundation
InventorsWilliam Fissell, H. Humes, Shuvo Roy, Aaron Fleischman
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Abstract
The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.
Claims23
An ultrafiltration system comprising:
- a) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5:1;
- b) a housing containing said membrane;
- and
- c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane.
1 more element
8-44. (canceled)
A method of filtering a biological fluid comprising:
- a) providing an ultrafiltration system comprising
- i) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5:1;
- ii) a housing containing said membrane;
- and
- iii) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane;
- b) connecting said system to a subject's vasculture;
- and
- c) passing biological fluid from said vasculature through said system to generate filtered biological fluid.
5 more elements
A method of filtering a biological fluid comprising:
- a) providing a bioartificial ultrafiltration device comprising:
- i) a housing;
- ii) an inlet port passing through said housing, said inlet port configured to receive a biological fluid;
- iii) an outlet port passing through said housing, said outlet port configured to return a biological fluid to a subject;
- iv) a membrane contained in said housing, said membrane comprising micromachined pores;
- and
- v) a population of cells attached to said membrane;
- b) connecting said system to a subject's vasculture;
- and
- c) passing biological fluid from said vasculature through said device to generate filtered biological fluid.
7 more elements
Dependencies are inferred from the claim text.