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AssigneeH:S Rigshospitalet and University of Prince Edward Island
InventorsTracy Doucette, Henriette Bak-Jensen, Melissa Perry, Catherine Ryan, R. Tasker
Estimating the term…
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.
1-8. (canceled)
A rodent which has been treated with low doses of a kainate receptor agonist during the second postnatal week, resulting in a permanment change in the neurological development of said rodent, wherein the rodent exhibits reproducible seizure-like symptoms when exposed to a mild to moderate stressor that would not normally elicit a seizure.
19-20. (canceled)
Dependencies are inferred from the claim text.