Neural stimulation for treatment of metabolic syndrome and type 2 diabetes
AssigneeLeptos Biomedical, Inc.
InventorJohn Dobak
Life of this patent
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Abstract
Systems and methods are described for treating metabolic syndrome and/or Type 2 diabetes, and/or one or more of their attendant conditions, by neural stimulation. In one embodiment, an implantable pulse generator is electrically coupled to a peripheral nerve, such as the splanchnic nerve. Neural stimulation configured to either block transmission or stimulate transmission of the peripheral nerve may be used to treat metabolic syndrome and Type 2 diabetes.
Claims36
A method, of treating at least one of metabolic syndrome and Type 2 diabetes, comprising electrically modulating a splanchnic nerve of a patient in a stimulation pattern that ameliorates or eliminates an attendant condition of said at least one of metabolic syndrome and Type 2 diabetes, said attendant condition comprising at least one of dyslipidemia, hypertension, hyperinsulinemia, hyperglycemia and insulin resistance.
A method, to increase lean muscle mass of a patient, comprising electrically modulating a sympathetic nerve of a patient in a stimulation pattern effective to increase a lean muscle mass of said patient.
A tissue modulation device, for treating at least one of metabolic syndrome and type 2 diabetes in a patient, comprising:
- a storage module having computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve of the patient;
- said pattern being effective to ameliorate at least one attendant condition of said at least one of metabolic syndrome and type 2 diabetes in said patient;
- and
- said attendant condition comprising at least one of dyslipidemia, hypertension, hyperinsulinemia, hyperglycemia, and insulin resistance.
A tissue modulation device comprising:
- a storage module having computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve;
- said pattern being effective to increase a lean muscle mass of said patient.
A tissue modulation device, for treating at least one of metabolic syndrome and type 2 diabetes in a patient, comprising:
- means for storing computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve of the patient;
- said pattern being effective to ameliorate at least one attendant condition of said at least one of metabolic syndrome and type 2 diabetes in said patient;
- and
- said attendant condition comprising at least one of dyslipidemia, hypertension, hyperinsulinemia, hyperglycemia, and insulin resistance.
A tissue modulation device comprising:
- means for storing computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve of the patient;
- said pattern being effective to increase a lean muscle mass of said patient.
A method, to increase a concentration of HDL in a patient, comprising:
- electrically modulating a sympathetic nerve of a patient in a stimulation pattern;
- said pattern being effective to increase the concentration of HDL of said patient.
A method, to decrease a concentration of LDL in a patient, comprising:
- electrically modulating a sympathetic nerve of a patient in a stimulation pattern;
- said pattern being effective to decrease the concentration of LDL in said patient.
A method, to decrease a concentration of serum cholesterol in a patient, comprising:
- electrically modulating a sympathetic nerve of a patient in a stimulation pattern;
- said pattern being effective to decrease the concentration of serum cholesterol in said patient.
A method, to reduce a concentration of serum triglycerides in a patient, comprising:
- electrically modulating a sympathetic nerve of a patient in a stimulation pattern;
- said pattern being effective to reduce the concentration of serum triglycerides in said patient.
A method, to treat hypertension in a patient, comprising:
- electrically modulating a sympathetic nerve of a patient in a stimulation pattern;
- said pattern being effective to ameliorate hypertension in said patient.
Dependencies are inferred from the claim text.