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US 2006/0190044 A1Published application
Cell therapy and neural stimulation for cardiac repair
AssigneeCardiac Pacemakers, Inc.
InventorsImad Libbus, Jeffrey Ross, Steven Girouard
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Abstract
A method and system to enhance cell, gene and/or cytokine therapy for cardiac repair in a mammal.
Claims38
A method, comprising:
- applying electrical stimulation to an efferent parasympathetic nerve which innervates cardiac tissue including one or more cardiac fat pads in a mammal with impaired cardiac function and subjected to exogenous cell therapy comprising donor cells, gene therapy and/or cytokine therapy, in an amount effective to modulate cardiac function.
A method, comprising:
- applying electrical therapy using a lead to an efferent parasympathetic nerve which innervates cardiac tissue including one or more cardiac fat pads of a mammal subjected to exogenous cell therapy comprising donor cells, gene therapy and/or cytokine therapy;
- sensing a physiologic parameter indicative of cardiac contractility, inflammation, mechanical remodeling, and/or mechanical loading;
- and
- modifying the electrical therapy based on the sensed physiological parameter.
1 more element
Dependencies are inferred from the claim text.