Material delivery system
AssigneeBy-Pass, Inc.
InventorsMordechay Beyar, Oren Globerman, Rami Keller
Life of this patent
Estimating the term…
Abstract
A method for injecting a therapeutic agent into a target tissue, the method comprising: (a) providing an expandable member; (b) positioning said expandable member in proximity to the target tissue; (c) Introducing the therapeutic agent into the expandable member until a desired pressure is achieved; and (d) creating a plurality of small apertures in the expandable member.
Claims57
A method for injecting a therapeutic agent into a target tissue, the method comprising:
- (a) providing an expandable member;
- (b) positioning said expandable member in proximity to the target tissue;
- (c) introducing the therapeutic agent into the expandable member until a desired pressure is achieved;
- and
- (d) creating a plurality of small apertures in the expandable member.
A method for reducing a toxic effect of a therapeutic agent on a non-target tissue, the method comprising:
- (a) providing an expandable member;
- (b) positioning said expandable member in proximity to a target tissue;
- (c) introducing an amount of therapeutic agent into the expandable member until a desired pressure is achieved;
- and
- (d) creating a plurality of small apertures, in the expandable member;
- wherein said amount is sufficient to exert a physiologic effect on cells of said target tissue but insufficient to exert an effect on cells lying at a distance greater than a selected distance from said target tissue.
A method for transmucosal delivery of a therapeutic agent to cells lining a body cavity, the method comprising:
- (a) providing an expandable member;
- (b) positioning said expandable member within the body cavity;
- (c) introducing the therapeutic agent into the expandable member until a desired pressure is achieved;
- and
- (d) creating a plurality of small apertures, in the expandable member;
- wherein said pressure is sufficient to propel said therapeutic agent through a mucosal layer to cells beneath said mucosal layer.
A method of treating a tissue, the method comprising:
- (a) bringing at least one elongate tube including a plurality of ports on its side in proximity to a tissue on an inner surface of a lumen;
- said tube characterized in that it cannot expand to fill the entire lumen;
- and
- (b) employing a pressure pulse to inject an agent into said tissue through the ports.
An apparatus for injecting a therapeutic agent into a target tissue, the apparatus comprising:
- (a) an expandable member including an outer wall characterized by a plurality of nascent holes therein, said outer wall defining an inner cavity;
- (b) a fill mechanism adapted to introduce a therapeutic agent into said inner cavity at a desired pressure;
- and
- (c) a release mechanism adapted to transform said nascent holes into actual holes.
An apparatus for reducing a toxic effect of a therapeutic agent on a non-target tissue, the apparatus comprising:
- (a) an expandable member including an outer wall characterized by a plurality of nascent holes therein, said outer wall defining an inner cavity, said expandable member adapted for positioning in proximity to a target tissue;
- (b) a fill mechanism adapted to introduce an amount of therapeutic agent into said inner cavity at a desired pressure;
- and
- (c) a release mechanism adapted to transform said nascent holes into actual holes;
- wherein said amount is sufficient to exert a physiologic effect on cells of said target tissue but insufficient to exert an effect on cells lying at a distance greater than a selected distance from said target tissue.
An apparatus for injecting a therapeutic agent into a target tissue, the apparatus comprising:
- (a) an expandable member characterized by at least one protrusion adapted for engagement by a lumen and at least a portion not engageable by said lumen and including an outer wall, said outer wall defining an inner cavity;
- (b) a fill mechanism adapted to introduce a therapeutic agent into said inner cavity at a desired pressure;
- and
- (c) a plurality of injection ports.
An apparatus for injecting a therapeutic agent into a target tissue, the apparatus comprising:
- (a) an expandable member including an outer wall, said outer wall defining an inner cavity;
- (b) a fill mechanism adapted to introduce a therapeutic agent into said inner cavity at a desired pressure;
- and
- (c) at least one injection port facing axially with respect to said device.
Dependencies are inferred from the claim text.