Process and intermediates for preparing emtricitabine
AssigneeArchimica GmbH
InventorsGiorgio Bertolini, Maurizio Deleo, Marco Frigerio, Massimo Losa, Maurizio Velati
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Abstract
A process is disclosed for the stereo-selective preparation of emtricitabine, which allows the desired product to be obtained in good yield and without the use of chromatographic techniques. The process for the production of emtricitabine of the formula (Ia) is characterized by the formation and isolation of intermediate compounds of formula (XIa) in salified form. Emtricitabine is a known antiviral drug.
Claims13
Process for preparing emtricitabine of formula
- which comprises the salification reaction of the intermediate compound of formula
- dissolved in a suitable solvent, by treatment with organic or mineral acids to give the corresponding salt.
Use of a salt of compound XIa as an intermediate for the preparation of emtricitabine (Ia).
Process for preparing the compound of formula
- which comprises the salification reaction of the intermediate compound of formula
- dissolved in a suitable solvent, by treatment with organic or mineral acids to give the corresponding salt, which is insoluble in the said solvent, in readily isolable solid form.
Dependencies are inferred from the claim text.