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US 2006/0189804 A1Published application
Synthetic method for the preparation of quinazolin-4-one derivative
OwnerAndrew Godfreyinventor
Life of this patent
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Abstract
A quinazolin-4-one derivative of formula (I), may be made by a process including the step of cyclization an amide of formula (II), to form a quinazolin-4-one derivative of formula (III).
Claims13
A process for the preparation of a quinazolin-4-one derivative of formula (I):
- where R1 and R2 are each independently hydrogen or methyl, PG is a protecting group and X is a leaving group;
- including the step of cyclization an amide of formula (II):
- wherein R1 and R2 are as defined above and Y is a leaving group;
- or a protected derivative thereof;
- to form a quinazolin-4-one derivative of formula (III):
- or a protected derivative thereof.
3 more elements
A process for the preparation of a quinazolin-4-one derivative of formula (I):
- where R1 and R2 are each independently hydrogen or methyl, PG is a protecting group and X is a leaving group;
- including the step of brominating a compound of formula (V):
- wherein R1 and R2 are as defined above and Y is a leaving group;
- or a protected derivative thereof;
- to form a compound of formula (IV)
- or a protected derivative thereof.
3 more elements
A quinazolin-4-one derivative of formula (III):
- where R1 and R2 are each independently hydrogen or methyl, and Y is a C1-4 acyloxy group or benzoyloxy.
An amide of formula (VIII):
- wherein R1 and R2 are each independently hydrogen or methyl, Y is a C1-4 acyloxy group or benzoyloxy and Z is Br or CN.
Dependencies are inferred from the claim text.