Magnetic polymer particles
OwnerPal Songe, Geir Fonnum +4inventors
InventorsPal Songe, Geir Fonnum, Nini Kjus, Marcel Sandeerg, Solveig Nordstrand, Inger Aukrust
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Abstract
A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand, optionally chelating a metal ion.
Claims25
A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate chelating ligand.
A conjugate comprising a magnetic polymer particle bound to a carboxymethylated aspartate ligand chelating a metal atom or ion.
A process for the preparation of a conjugate comprising a magnetic polymer particle bound to a Cm-Asp ligand comprising reacting a Cm-Asp ligand of formula (II)
- (wherein each R independently represents hydrogen or a protecting group and X represents a 2 to 20 atom group) with a magnetic polymer particle, and optionally coordinating the resulting conjugate to a metal atom or ion.
A compound of formula (II)
- (wherein each R independently represents hydrogen or a protecting group and X represents a 2 to 20 atom group) or an analogue therefore in which the R groups are absent and a metal chelated.
A compound of formula (III) or an analogue thereof in which a metal is
A process for the preparation of a compound of formula
- (wherein each R independently represents hydrogen or a protecting group and X represents an C2-20 alkylene linker);
- comprising reacting a compound of formula Hal-X1 —CN (wherein Hal is a halide and X1 represents an C1-19 alkylene linker) with a compound of formula
- (wherein Pr is a protecting group)
- reacting the resulting product with a compound of formula Hal-CH2COOPr to form a compound
- reducing the nitrile to an amino group;
- and optionally deprotecting the carboxyl groups.
Dependencies are inferred from the claim text.