US 2006/0189701 A1 · Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections

Abstract

A method for killing infectious microbial cells by exposing the microbial cells to endogenous antimicrobial compounds. Activation of the antimicrobials is achieved by addition of low permeability, non-ionic osmolytes to lower ionic strength in body fluids where the antimicrobials have been previously suppressed by alteration of ionic transport (increase in salt concentration). The method can be used to treat cystic fibrosis. Cystic fibrosis causes elevated salt concentrations in the airway surface liquid (ASL) occur due to the impaired chloride transport across the epithelia. Xylitol has been found to be an effective low permeability, non-ionic osmolyte for use in the present invention.

Claims10

Dependent claims

A method of killing infectious cells comprising:

administering to an epithelium surface an effective amount of a non-ionic osmolyte,
wherein said surface has a fluid containing endogenous antimicrobials, thereby reducing the ionic strength of said fluid containing said endogenous antimicrobials and promoting antimicrobial activity against infectious cells.

Dependencies are inferred from the claim text.

Facts

Application

11/405,345Filed 17 Apr 2006

Priority

19 May 2000

Published

24 Aug 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

A61K 31/045
Medicinal preparations containing organic active ingredients: hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/047
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates: having two or more hydroxy groups, e.g. sorbitol
A61K 9/0075
Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy: for inhalation via a dry…
A61K
Medicines and medical preparations

Family

Application60/205,948Us provisional application · filed 19 May 2000

Application09/861,841Continuation · filed 21 May 2001

Application10/766,506Continuation · filed 28 Jan 2004

Application11/405,345Continuation · filed 17 Apr 2006

US 2002/0022668 A1Published application

US 2004/0192786 A1Published application

US 6,716,819 B2Related patent

US 2006/0189701 A1This patent

From the US filing history. Foreign family members aren’t listed.

Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections

Life of this patent

Use of xylitol to reduce ionic strength and activate endogenous antimicrobials for prevention and treatment of infections

Life of this patent

Abstract

Claims10