Polyamine conjugates with acidic retinoids and preparation thereof
OwnerDionysios Papaioannou, Dionvsios Drainas +1inventors
InventorsDionysios Papaioannou, Dionvsios Drainas, Dionysios Tsambaos
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Abstract
Invented are novel polyamine conjugates which have been readily obtained using as key-step the condensation of linear, conformationally restricted, cyclic and branched polyamides or suitably protected derivatives with vitamin A derivatives. These compounds inhibit the ribozyme rivbonuclease P (RNase P) and the production of interleukin-2 (IL-2) amd interferon-γ (INF-γ) by peripheral blood mononuclear cells in vitro.
Claims11
Conjugates of polyamines with acidic retinoids and in particular polyamine amides in which the R group of the acyl group(s) RCO is one of the retinoid residues R1-R6 pointed out in the following pharmaceutically important acidic retinoids and polyene chain-shortened all-trans-retinoic acid analogues:
Dependencies are inferred from the claim text.