Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
AssigneeAgouron Pharmaceuticals, Inc.
InventorsAllen Borchardt, Javier Gonzalez, Hui Li, Maria Linton, John Tatlock
Life of this patent
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Abstract
The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
Claims20
A compound of the formula,
- wherein:
- R10 and R11 are each independently selected from hydrogen and C1-C10 alkyl, provided that both R10 and R11 are not hydrogen;
- or
- R10 and R11, together with the atom to which they are attached, form a C3-C10 cycloalkyl group;
- and
- R4a, R4b, R4c, and R4d are each independently selected from hydrogen, halo, C1-C10 alkyl, —CF3, and —OCH3, provided that R4b and R4c are not both hydrogen.
A compound according to 5, wherein R4a and R4d are each hydrogen, and R4b and R4c are independently selected from hydrogen, halo, C1-C10 alkyl, and —CF3, provided that R4b and R4c are not both hydrogen.
A compound of the formula,
- wherein:
- R10 and R11 are each independently selected from hydrogen and C1-C10 alkyl, provided that both R10 and R11 are not hydrogen;
- or
- R10 and R11, together with the atom to which they are attached, form a C3-C10 cycloalkyl group;
- and
- R4a, R4b, R4c, and R4d are each independently selected from hydrogen, halo, C1-C10 alkyl, —CF3, and —OCH3, provided that R4b and R4c are not both hydrogen.
A compound according to 16, wherein R4a and R4d are each hydrogen, and R4b and R4c are independently selected from hydrogen, halo, C1-C10 alkyl, and —CF3, provided that R4b and R4c are not both hydrogen.
Dependencies are inferred from the claim text.