Ion channel modulating compounds and uses thereof

A method for blocking cardiac early repolarizing currents and cardiac sodium currents in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.

A method to block sodium or potassium ion channels in vitro comprising contacting a preparation containing sodium ion channels or potassium ion channels with an effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.

A method to block sodium or potassium ion channels in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.

A method for treating, in a warm-blooded animal, a disease selected from the group consisting of arrhythmia, convulsion, epileptic spasm, depression, anxiety, schizophrenia, Parkinson's disease, cystic fibrosis, asthma, cough, arthritis, urinary incontinence, irritable bowel syndrome, cerebral or myocardial ischemias, long-QT syndrome, stroke, migraine, diabetes mellitus, Becker's myotonia, myasthenia gravis, paramyotonia congentia, malignant hyperthermia, hyperkalemic periodic paralysis, Thomsen's myotonia, graft rejection in organ transplantation or bone marrow transplantation, heart failure, Alzheimer's disease, and alopecia, the method comprising administering to said animal a therapeutically effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.

A method to produce local analgesia or anesthesia in a warm-blooded animal comprising administering to said animal a therapeutically effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.

A method for treating impotence or increasing libido in a male warm-blooded animal comprising administering to said animal a therapeutically effective amount of a composition comprising a compound having the following structure:

• as an isolated enantiomeric or diastereomeric isomer or as a mixture thereof, or as a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier, excipient or diluent.