Crystalline form of a drug
OwnerSteve Kinginventor
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Abstract
Atrasentan Hydrochloride Crystalline Form 1, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
Claims8
Atrasentan Hydrochloride Crystalline Form 1 characterized, when measured at about 25° C. with Cu—Kα radiation, by a powder diffraction pattern with at least three peaks having respective 2θ values of about 8.3°, 9.7°, 10.0°, 13.0°, 15.6°, 17.2° or 19.5°.
A composition made with an excipient and Atrasentan Hydrochloride Crystalline Form 1.
A method for treating prostate cancer in a human comprising administering thereto a therapeutically effective amount of Atrasentan Hydrochloride Crystalline Form 1.
A method for treating nociception in a human comprising administering thereto a therapeutically effective amount of Atrasentan Hydrochloride Crystalline Form 1.
A method for treating bone pain associated with bone cancer in a human comprising administering thereto a therapeutically effective amount of Atrasentan Hydrochloride Crystalline Form 1.
A method for inhibiting bone metastases in a human having prostate cancer that has metastasized to bone comprising administering thereto a therapeutically effective amount of Atrasentan Hydrochloride Crystalline Form 1.
A process for making Atrasentan Hydrochloride Crystalline Form 1 having substantial crystalline purity, the process comprising the acts of:
- providing a mixture comprising a solvent and atrasentan, wherein the atrasentan is completely dissolved in the solvent;
- and
- causing crystalline atrasentan hydrochloride to exist in the mixture, the crystalline atrasentan hydrochloride, when isolated and measured at about 25° C. with Cu—Kα radiation, characterized by a powder diffraction pattern with at least three peaks having respective 2θ values of about 8.3°, 9.7°, 10.0°, 13.0°, 15.6°, 17.2° or 19.5°, or by a combination thereof;
- and
- isolating the Atrasentan Hydrochloride Crystalline Form 1.
Dependencies are inferred from the claim text.