Compounds, compositions, and methods

A compound selected from the group represented by Formula I:

• wherein:
• T and T′ are independently a covalent bond or optionally substituted lower alkylene;
• R1 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R2 and R2′ are independently chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• or R2 and R2′ taken together form an optionally substituted 3-to 7-membered ring;
• R3 is chosen from hydrogen, optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaryl-, optionally substituted heteroaralkyl-, —C(O)—R6, and —S(O)2—R6a;
• R4 is independently chosen from hydrogen, optionally substituted alkyl, carboxyalkyl, aminocarbonyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, optionally substituted heterocyclyl and optionally substituted heteroaryl;
• R5 is chosen from hydrogen, optionally substituted alkyl-, optionally substituted aryl-, optionally substituted aralkyl-, optionally substituted heteroaralkyl-, and optionally substituted heterocyclyl-;
• or R5 taken together with R3, and the nitrogen to which they are bound, form an optionally substituted 5- to 12-membered nitrogen-containing heterocycle, which optionally incorporates from one to two additional heteroatoms, selected from N, O, and S in the heterocycle ring;
• or R5 taken together with R2 form an optionally substituted 5- to 1 2-membered nitrogen-containing heterocycle, which optionally incorporates from one to two additional heteroatoms, selected from N, O, and S in the heterocycle ring;
• R6 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, R7O— and R11—NH—;
• R6a is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, and R11—NH—;
• R7 is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• R11 is chosen from hydrogen, optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, and optionally substituted heteroaralkyl;
• a pharmaceutically acceptable salt of a compound of Formula I;
• a pharmaceutically acceptable solvate of a compound of Formula I;
• or
• a pharmaceutically acceptable solvate of a pharmaceutically acceptable salt of a compound of Formula I,
• provided that R1 is not optionally substituted phenyl when R4 is optionally substituted phenyl.