Piperidine derivatives and agent comprising the derivative as active ingredient
AssigneeOno Pharmaceutical Co., Ltd.
InventorsHisao Nakai, Katsuya Kishikawa
Life of this patent
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Abstract
Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia and the like.
Claims17
A method for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia or AIDS, which comprises administering to a subject in need thereof an effective amount of a piperidine derivative compound represented by formula (I):
- wherein R1 represents 1) a hydrogen atom or 2) a cyano group;
- R2 and R3 each independently represents 1) a C1-8 alkyl group, 2) a C3-7 cycloalkyl group, 3) a C1-8 alkyl group substituted with a C3-7 cycloalkyl group, 4) a C1-8 alkyl group substituted with 1 to 3 halogen atom(s), 5) a hydrogen atom, 6) a C1-8 alkyl group substituted with a phenyl group, 7) a C1-8 alkyl group substituted with a C1-8 alkoxy group, or
- in which n represents 1 to 5;
- R4 and R5 each independently represents 1) a hydrogen atom or 2) a C1-8 alkyl group, or
- R4 and R5 are taken together with the binding carbon atom to represent a C3-7 saturated carbocyclic ring;
- R6 represents 1) a hydroxyl group, 2) a C1-8 alkoxy group, 3) —NHOH, or 4) a C1-8 alkoxy group substituted with a phenyl group;
- and
- m is 0 or an integer of 1 to 4,
- or a nontoxic salt thereof.
A method for inhibition of PDE4, which comprises administering to a subject in need thereof an effective amount of a piperidine derivative compound represented by formula (I):
- wherein R1 represents 1) a hydrogen atom or 2) a cyano group;
- R2 and R3 each independently represents 1) a C1-8 alkyl group, 2) a C3-7 cycloalkyl group, 3) a C1-8 alkyl group substituted with a C3-7 cycloalkyl group, 4) a C1-8 alkyl group substituted with 1 to 3 halogen atom(s), 5) a hydrogen atom, 6) a C1-8 alkyl group substituted with a phenyl group, 7) a C1-8 alkyl group substituted with a C1-8 alkoxy group, or
- in which n represents 1 to 5;
- R4 and R5 each independently represents 1) a hydrogen atom or 2) a C1-8 alkyl group, or
- R4 and R5 are taken together with the binding carbon atom to represent a C3-7 saturated carbocyclic ring;
- R6 represents 1) a hydroxyl group, 2) a C1-8 alkoxy group, 3) —NHOH, or 4) a C1-8 alkoxy group substituted with a phenyl group;
- and
- m is 0 or an integer of 1 to 4,
- or a nontoxic salt thereof.
Dependencies are inferred from the claim text.