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US 2006/0189646 A1Published application
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AssigneeBoehringer Ingelheim Pharmaceuticals, Inc.
InventorsDaniel Kuzmich, Darren DiSalvo, John Regan, David Thomson, Rajashekhar Betageri, Jennifer Kowalski
Life of this patent
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Abstract
Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
Claims13
A compound selected from:
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-c]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[3,2-c]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trichloro-N-[2,2,2-trifluoro-1-(5-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[3,2-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- N-[1-(3-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 4-Chloro-2-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzimidazol-1-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dichloro-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4-chloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-2-ylmethylethyl)benzenesulfonamide;
- N-[1-(6-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,6-Dichloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]-4-trifluoromethylbenzenesulfonamide;
- 2,4,6-Trifluoro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-oxo-4H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,6-Dichloro-4-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-methyl-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3,4-Dihydro-2H-quinolin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-hydroxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Benzyloxy-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-5-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-6-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzo[b]thiophen-3-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Ethyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dimethyl-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(1-methylpyrido[3,4-b]indol-9-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methoxy-1-methylpyrido[3,4-b]indol-9-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(1,2,3,4-tetrahydrocarbazol-9-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Carbazol-9-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3,6-Dibromocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- N-[1-(2,3-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Chloro-2-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,5-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Acetylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Dimethylaminomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Dimethylaminomethyl-5-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- {1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetic acid ethyl ester;
- 2-{1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetamide;
- N-(2-{5-Methoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}ethyl)acetamide;
- N-[1-(4-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5,6-Dimethoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 9-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(6-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-5-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-7-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxy-3-cyanomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2,3,7-trimethylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-{1-[2-(4-Chlorophenyl)indol-1-ylmethyl]-2,2,2-trifluoroethyl}-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-{2,2,2-trifluoro-1-[2-(4-fluorophenyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2,3-dicarboxylic acid dimethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 4-Methoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- 6-Methoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- 4,6-Dimethoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(7-Ethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-5-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-{2,2,2-trifluoro-1-[3-(2,2,2-trifluoroacetyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-4-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-6-carboxylic acid methyl ester;
- N-[1-(2,3-Dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-trifluoromethylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(6-Chloro-1,2,3,4-tetrahydrocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-2-phenylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3-Dimethylaminomethyl-6-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid ethyl ester;
- {2-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetic acid ethyl ester;
- N-[1-(7-Chloro-2,3-dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-5-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-2-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 5-Benzyloxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 5-Chloro-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 5-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,3-Dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-2,3-dihydroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Bromo-2,3-dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-N-[1-(7-cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dimethylbenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(7-cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-N-[1-(7-cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dimethylbenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(7-cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Cyano-N-[1-(7-cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dimethylbenzenesulfonamide;
- 2,4-Dichloro-6-cyano-N-[1-(7-cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(7-cyano-5-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- N-[1-(7-Cyano-5-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(7-cyano-4-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(7-cyano-6-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- N-[1-(7-Cyano-4-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-6-fluoro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2-dimethylamino-4,6-dimethylbenzenesulfonamide;
- 2,4-Dichloro-N-[1-(7-cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-6-dimethylaminobenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-methylpyrrolo[2,3-b]pyridin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3-Cyanopyrrolo[2,3-b]pyridin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethylpyrrolo[2,3-b]pyridin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-phenylpyrrolo[2,3-b]pyridin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-pyrimidin-5-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-pyridin-4-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-pyridin-3-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-pyridin-2-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(3-cyanomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(4-fluoro-3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(5-fluoro-3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(6-fluoro-3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(7-fluoro-3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-trifluoromethylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(3-ethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-N-[1-(5-chloro-7-cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dimethylbenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(5-chloro-7-cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(5-chloro-3-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[1-(3-cyanomethyl-5-fluoroindol-1-ylmethyl)-2,2,2-trifluoroethyl]benzenesulfonamide;
- 1-[2-(2-Amino-4,6-dichlorobenzenesulfonylamino)-3,3,3-trifluoropropyl]-1H-indole-3-sulfonic acid dimethylamide;
- 1-[2-(2-Amino-4,6-dichlorobenzenesulfonylamino)-3,3,3-trifluoropropyl]-1H-indole-3-sulfonic acid amide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(7-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-N-[1-(3-benzylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dichlorobenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-isoxazol-3-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[3-(1H-pyrazol-3-yl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-oxazol-2-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[3-(1H-imidazol-2-yl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-isoxazol-4-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[3-(1H-pyrazol-4-yl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 2-Amino-N-[1-(3-cyanomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-4,6-dimethylbenzenesulfonamide;
- 2,4-Dichloro-N-[1-(7-cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-6-hydroxybenzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[3-(1-methyl-1H-pyrazol-4-yl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-piperidin-4-ylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{2,2,2-trifluoro-1-[3-(4-fluorophenyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-{1-[3-(4-dimethylaminophenyl)indol-1-ylmethyl]-2,2,2-trifluoroethyl}benzenesulfonamide;
- and
- 2-Amino-4,6-dichloro-N-[2,2,2-trifluoro-1-(3-methoxymethylindol-1-ylmethyl)ethyl]benzenesulfonamide,
- or a tautomer, prodrug, solvate, or salt thereof.
194 more elements
A compound selected from:
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-c]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[3,2-c]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trichloro-N-[2,2,2-trifluoro-1-(5-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[3,2-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- N-[1-(3-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 4-Chloro-2-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzimidazol-1-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dichloro-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4-chloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-2-ylmethylethyl)benzenesulfonamide;
- N-[1-(6-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,6-Dichloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]-4-trifluoromethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-oxo-4H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,6-Dichloro-4-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4,6-dichloro-N-methyl-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3,4-Dihydro-2H-quinolin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-hydroxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Benzyloxy-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-5-carboxylic acid methyl ester;
- (1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-6-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzo[b]thiophen-3-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Ethyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dimethyl-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(1,2,3,4-tetrahydrocarbazol-9-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Carbazol-9-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3,6-Dibromocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- N-[1-(2,3-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Chloro-2-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,5-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Acetylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Dimethylaminomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- {1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetic acid ethyl ester;
- 2-{1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetamide;
- N-[1-(4-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5,6-Dimethoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(6-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-5-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-7-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxy-3-cyanomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-{1-[2-(4-Chlorophenyl)indol-1-ylmethyl]-2,2,2-trifluoroethyl}-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-{2,2,2-trifluoro-1-[2-(4-fluorophenyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2,3-dicarboxylic acid dimethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 4-Methoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(7-Ethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-5-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-{2,2,2-trifluoro-1-[3-(2,2,2-trifluoroacetyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-4-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-6-carboxylic acid methyl ester;
- N-[1-(2,3-Dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-trifluoromethylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(6-Chloro-1,2,3,4-tetrahydrocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-2-phenylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(7-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid ethyl ester;
- {2-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetic acid ethyl ester;
- N-[1-(7-Chloro-2,3-dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-5-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 5-Benzyloxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,3-Dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-2,3-dihydroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Bromo-2,3-dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- and
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-trifluoromethyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide,
- or a tautomer, prodrug, solvate, or salt thereof.
127 more elements
A compound selected from:
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trichloro-N-[2,2,2-trifluoro-1-(5-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[3,2-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- N-[1-(3-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-(1-Benzimidazol-1-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dichloro-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino-4-chloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indazol-2-ylmethylethyl)benzenesulfonamide;
- N-[1-(6-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,6-Dichloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]-4-trifluoromethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-oxo-4H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,6-Dichloro-4-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2-Amino 4,6-dichloro-N-methyl-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloro-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methoxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3,4-Dihydro-2H-quinolin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-hydroxy-4-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(4-Benzyloxy-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-5-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-6-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzo[b]thiophen-3-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Ethyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4-Dimethyl-6-nitro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(1,2,3,4-tetrahydrocarbazol-9-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Carbazol-9-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3,6-Dibromocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- N-[1-(2,3-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Chloro-2-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxy-2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,5-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Acetylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- {1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetic acid ethyl ester;
- 2-{1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indol-3-yl}acetamide;
- N-[1-(4-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5,6-Dimethoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(6-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-5-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Benzyloxy-3-cyanomethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxyindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-{1-[2-(4-Chlorophenyl)indol-1-ylmethyl]-2,2,2-trifluoroethyl}-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-{2,2,2-trifluoro-1-[2-(4-fluorophenyl)indol-1-ylmethyl]ethyl}benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2,3-dicarboxylic acid dimethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 4-Methoxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(7-Ethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-5-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-4-carboxylic acid methyl ester;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-6-carboxylic acid methyl ester;
- N-[1-(2,3-Dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-trifluoromethylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid methyl ester;
- N-[1-(6-Chloro-1,2,3,4-tetrahydrocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-2-phenylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(7-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2-Methyl-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-3-carboxylic acid ethyl ester;
- N-[1-(7-Chloro-2,3-dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-5-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 5-Benzyloxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- and
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide,
- or a tautomer, prodrug, solvate, or salt thereof.
111 more elements
A compound selected from:
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-indol-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-methylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-(2,2,2-trifluoro-1-pyrrolo[2,3-b]pyridin-1-ylmethylethyl)benzenesulfonamide;
- 2,4,6-Trichloro-N-[2,2,2-trifluoro-1-(5-methyl-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(3-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(3-phenylindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,6-Dichloro-N-[2,2,2-trifluoro-1-(1H-indol-3-ylmethyl)ethyl]-4-trifluoromethylbenzenesulfonamide;
- N-[1-(4-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Cyanoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoro-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloro-H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3,4-Dihydro-2H-quinolin-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-hydroxy-1H-indol-3-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-methoxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1,2,3,4-tetrahydroquinoline-6-carboxylic acid methyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-hydroxy-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- N-(1-Benzo[b]thiophen-3-ylmethyl-2,2,2-trifluoroethyl)-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Bromo-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Cyano-5-methyl-1H-indol-3-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3,6-Dibromocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(5-Chloro-2-methylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Acetylindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(5-Benzyloxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(6-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(2,3-Dimethyl-5-nitroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(4-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-5-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 1-[3,3,3-Trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-5-carboxylic acid methyl ester;
- N-[1-(6-Chloro-1,2,3,4-tetrahydrocarbazol-9-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(4-Bromoindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(7-fluoroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(7-Chloroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(7-Chloro-2,3-dihydro-1H-cyclopent[b]indol-4-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- N-[1-(3-Cyanomethyl-5-methoxyindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 5-Benzyloxy-1-[3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propyl]-1H-indole-2-carboxylic acid ethyl ester;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(6-nitroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- N-[1-(2,3-Dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-2,3-dihydroindol-1-ylmethyl)ethyl]benzenesulfonamide;
- 2,4,6-Trimethyl-N-[2,2,2-trifluoro-1-(2-methyl-3,4-dihydro-2H-quinolin-1-ylmethyl)ethyl]benzenesulfonamide;
- and
- N-[1-(5-Bromo-2,3-dihydroindol-1-ylmethyl)-2,2,2-trifluoroethyl]-2,4,6-trimethylbenzenesulfonamide, or a tautomer, prodrug, solvate, or salt thereof.
53 more elements
Dependencies are inferred from the claim text.