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US 2006/0189641 A1Published application
Novel 6-phenlyphenanthridines
OwnerBeate Schmidtinventor
Life of this patent
Estimating the term…
Abstract
Compounds of a certain formula (I) in which R1, R2, R3, R31, R4, R5, R51, R6, R7 and R8 have the meanings indicated in the description, are novel effective PDE4 inhibitors.
Claims11
A compound of the formula I,
- in which
- R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
- R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
- or in which R1 and R2 together are a 1-2C-alkylenedioxy group,
- R3 is hydrogen or 1-4C-alkyl,
- R31 is hydrogen or 1-4C-alkyl, p1 or in which R3 and R31 together are a 1-4C-alkylene group,
- R4 is hydrogen or 1-4C-alkyl,
- R5 is hydrogen,
- R51 is hydrogen,
- or in which R5 and R51 together represent an additional bond,
- R6 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R7 is 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, pyridinyl, phenyl or R71- and/or R72-substituted phenyl, wherein
- R71 is halogen, hydroxyl, cyano, trifluoromethyl, carboxyl, nitro, 1-4C-alkyl or 1-4C-alkoxy,
- R72 is 1-4C-alkoxy, 1-4C-alkyl or halogen,
- R8 is hydrogen, phenyl, 1-4C-alkyl, aryloxy-2-4C-alkyl or R9-substituted 1-4C-alkyl, wherein
- aryloxy is phenoxy or R81-substituted phenoxy, wherein
- R81 is halogen or trifluoromethyl,
- R9 is phenyl, C(O)N(R91)R92 or R93-substituted phenyl, wherein
- R91 is phenyl, aryl-1-4C-alkyl or R911-substituted phenyl, wherein
- aryl is phenyl or R81-substituted phenyl,
- R911 is 1-4C-alkoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
- R92 is hydrogen,
- or wherein R91 and R92, together and including the nitrogen atom to which both are bound, represent a 1-pyrrolidinyl, 1-piperidinyl, 1-piperazinyl, 4-methylpiperazin-1-yl, 4-phenylpiperazin-1-yl, 1-hexahydroazepinyl or 4-morpholinyl radical,
- R93 is nitro, 1-4C-alkyl, 1-4C-alkoxycarbonyl, halogen, trifluoromethyl, 1-4C-alkoxy or completely or predominantly fluorine-substituted 1-4C-alkoxy,
- or a salt or an E/Z isomer thereof.
22 more elements
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(canceled)
Dependencies are inferred from the claim text.