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US 2006/0189638 A1Published application
4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
AssigneeLexicon Pharmaceuticals, Inc.
InventorsDavid Rawlins, Michael Voronkov, Yulian Zhang
Life of this patent
Estimating the term…
Abstract
Substituted 4-piperidin-1-yl-7H-pyrrolo[2,3-D]pyrimidine compounds are disclosed, as well as compositions comprising them and methods of their use for the treatment, prevention and management of various diseases and disorders.
Claims32
A compound of the formula:
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- A1 and A2 are each independently optionally substituted aryl or heteroaryl;
- X is —CH2— or —C(O)—;
- Y is —O—, —NR5—, —S(O)nNR5—, —C(O)NR5—, —NR5C(O)—, —C(O)—, or —S(O)n—;
- n is 1 or 2;
- R1 and R2 are each independently hydrogen, halo, cyano, hydroxy, —NR3R4, thio, or optionally substituted alkyl, alkoxy, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl;
- and
- R3, R4, and R5 are each independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl.
5 more elements
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(canceled)
A compound of the formula:
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- A1 is optionally substituted aryl or heteroaryl;
- X is —CH2— or —C(O)—;
- Y is —O—, —NR5—, —S(O), —NR5—, —C(O)NR5—, —NR5C(O)—, —C(O)—, or —S(O)n—;
- n is 1 or 2;
- R1 and R2 are each independently hydrogen, halo, cyano, hydroxy, —NR3R4, thio, or optionally substituted alkyl, alkoxy, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl;
- and
- R3, R4, and R5 are each independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl;
- and
- R6 is hydrogen, halo, cyano, hydroxy, alkoxy, amino or optionally substituted alkyl.
7 more elements
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A compound of the formula:
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- A2 is optionally substituted aryl or heteroaryl;
- X is —CH2— or —C(O)—;
- Y is —O—, —NR5—, —S(O)nNR5—, —C(O)NR5—, —NR5C(O)—, —C(O)—, or —S(O)n—;
- n is 1 or 2;
- R1 and R2 are each independently hydrogen, halo, cyano, hydroxy, —NR3R4, thio, or optionally substituted alkyl, alkoxy, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl;
- and
- R3, R4, and R5 are each independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, heterocycle or heterocycloalkylalkyl.
5 more elements
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.