Substituted imidazopyrimidines for the prevention and treatment of cancer

A compound of general formula (I),

• stereoisomers and mixtures thereof, polymorphs and mixtures thereof, and pharmaceutically acceptable solvates and addition salts of them all,
• wherein:
• A1, A2, A3, A4, A5, B1, B2, B3, B4 and B5 are radicals independently selected from the group consisting of H, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, CF3, OCF3, CN, (CH2)nOR1, (CH2)nNR1R2, CONR1R2, F, Cl, Br, I, NR1R2, NR2COR1, OR1, COR1, COOR1, COSR1, OCOR1, SR1, SOR1, S(O)OH, SO2R1, SO2NR2R3, SO2NHCOR1, and SCOR1;
• wherein n is an integer from 1 to 3;
• R1 is a radical selected from H, CH2OCOR2, CF3, (C1-C4)-alkyl, and (C3-C7)-cycloalkylmethyl and (C3-C7)-cycloalkyl;
• R2 is a radical selected from H, and (C1-C4)-alkyl;
• R3 is a radical selected from COR1, and SO2R1;
• alternatively, A2, A3, B2 or B3 may represent NO2;
• alternatively, either A2 and A3, or B2 and B3 may be forming a R4—(C1-C3)-alkyl-R5 biradical, wherein R4 and R5 are independently selected from CR1R2, O, NR1, S;
• and
• P1, P2, and P3 are radicals independently selected from the group consisting of H, NR1R2, NR2COR1, CF3, F, Cl, Br, OH, SH, (C1-C4)-alkyl, (C1-C4)-alkoxyl and (C1-C4)-alkylsulfanyl,
• with the proviso that formula (I) does not include any of the following compounds:
• (a) simultaneously B3 is SO2NH2 or SO2CH3, A3, A4 or A5 are H, F, Cl, Br, (C1-C3)-alkyl, CF3, (C1-C3)-alkoxyl or OCF3, and P1 or P2 are H, CH3, Cl, Br or CH3O;
• (b) simultaneously B3 is CH3O or H, A3 is CH3O or H, and P1, P2 and P3 are H;
• (c) simultaneously B3 is F, A3 is SO2CH3, and P1 is methyl;
• (d) simultaneously A1, A2, A3, A4, A5, B1, B2, B3, B4, B5 are H, P1 is methyl, P2 is H and P3 is OH;
• (e) simultaneously A3 and B3 are CH3O, A1, A2, A4, A5, B1, B2, B4 and B5 are H, and one of the groups P1, P2 or P3 are H, OH, (C1-C4)-alkyl or (C1-C4)-alkoxyl, being the remaining two groups P1, P2 or P3 representing H;
• or
• (f) simultaneously A3 and B3 are CH3O, A1, A2, A4, A5, B1, B2, B4 and B5 are H, P1 is OH or (C1-C4)-alkoxyl, P2 is H and P3 is (C1-C4)-alkyl.