Cyclic aminophenyl sulfamate derivative
AssigneeAska Pharmaceutical Co., Ltd.
InventorsShigehiro Takegawa, Shigeki Iwashita, Makoto Okada, Takayoshi Nakagawa, Naoyuki Koizumi, Tomohito Fujii
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Abstract
This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula wherein each of R1 and R2 stands for hydrogen or lower alkyl; each of R3 and R4 stands for hydrogen, halogen, cyano or the like; A stands for nitrogen or CH; B stands for CH2, SO2, CO, optionally substituted phenyl or the like; and R5 stands for alkyl, phenyl, amino or the like, or salts thereof which exhibit excellent steroid sulfatase inhibitory activity and are useful for prevention or treatment of diseases associated with steroids such as estrogen, androgen and the like.
Claims27
Cyclicamino-phenyl sulfamate derivatives represented by the following formula:
- wherein
- R1 and R2 stand for, independently from each other, hydrogen or lower alkyl,
- R3 and R4 stand for, independently from each other, hydrogen, halogen, cyano or lower alkyl,
- A stands for nitrogen or CH,
- B stands for CH2, SO2, CO, CH═CH or substituted or unsubstituted phenylene, and
- R5 stands for hydrogen, straight chain or branched chain C1-C10 alkyl, phenyl-lower alkyl (in which the phenyl moiety may be further substituted), benzoyl-lower alkyl (in which the phenyl moiety in the benzoyl may be further substituted), cycloalkyl-lower alkyl, piperidinyl-lower alkyl, substituted or unsubstituted phenyl, substituted or unsubstituted benzoyl or amino (in which the amino may be further substituted with lower alkyl or may form cyclic amino group)
- or salts thereof.
Dependencies are inferred from the claim text.