Pyridazinone and triazinone compounds and use thereof as pharmaceutical preparations

A compound represented by the following formula (I), a salt thereof or a hydrate thereof:

• wherein in formula (I) A1, A2 and A3 are independent of each other, and wherein
• each of A2 and A3 represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which is optionally substituted, and
• A1 represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which is optionally substituted,
• wherein at least one of A2 and A3 always represents the 5- to 14-membered non-aromatic heterocyclic group (provided that piperidinyl group, 2,4-dihydropyrazol-3-one-yl group and pyrimidinetrione-yl group are excluded) or at least one of A1, A2 and A3 represents the 5- to 14-membered aromatic heterocyclic group (provided that indolyl group and pyrazolyl group are excluded);
• Q represents O, S or NH;
• Z represents C;
• X1, X2 and X3 are independent of each other, and wherein
• X1 represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —O—, —N(R4)CO—, —CON(R5)—, —CH2N(R7)—, —CH2CO—, —COCH2—, —N(R8)SO0-2—, —SO0-2N(R9)—, —CH2SO0-2—, —SO0-2CH2—, —CH2—, —OCH2—, —N(R10)CON(R11)—, —N(R12)CS—N(R13)— or —SO0-2—, wherein R4, R5, R7, R8, R9, R10, R11, R12 and R13 are independent of each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group,
• X2 represents a single bond, —NH—, —O—, —CON(R5)—, —N(R6)CH2—, —CH2N(R7)—, —N(R8)SO0-2—, —SO0-2N(R9)—, —CH2SO0-2—, —SO0-2CH2—, —CH2O—, —OCH2—, —N(R10)CON(R11)—, —N(R12)CS—N(R13)— or —SO0-2—, wherein R5, R6, R7, R8, R9, R10, R11, R12 and R13 are independent of each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, and
• X3 represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —N(R4)CO—, —CON(R5)—, —N(R6)CH2—, —CH2N(R7)—, —CH2CO—, —COCH2—, —N(R8)SO0-2—, —SO0-2N(R9)—, —CH2SO0-2—, —SO0-2CH2—, —CH2O—, —OCH2—, —N(R10)CON(R11)—, —N(R12)CS—N(R13)— or —SO0-2—, wherein R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are independent of each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group;
• R1 and R2 are independent of each other and each represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group, or R1 and R2 may be bound to each other such that CR2-ZR1 forms a carbon-carbon double bond represented by C═C;
• R3 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group or an optionally substituted C2-6 alkynyl group.