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US 2006/0189619 A1Published application
3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
AssigneeWyeth
InventorsAbdolsamad Tadayon, Jacqueline Lunetta, Kiomars Karami, Zheng Wang
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Abstract
The present invention relates to Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
Claims26
A compound which is the amorphous, ethanolate, or hydrate form of 3-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]pyrazine.
A method for converting amorphous 3-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]pyrazine to a hydrate form, the method comprising:
- dissolving amorphous 3-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]pyrazine in ethanol;
- obtaining the ethanolate form of 3-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl} methyl)pyrido[2,3-b]pyrazine;
- contacting the ethanolate form with water at a temperature above 25° C.;
- and
- crystallizing to obtain the hydrate form of 3-({4-[2-(4-tert-butylphenyl)-1H-benzimidazol-4-yl]piperazin-1-yl methyl)pyrido[2,3-b]pyrazine.
2 more elements
Dependencies are inferred from the claim text.