Sulphonamide Compounds that Modulate Chemokine Receptor Activity (CCR4)

A compound of formula (I) and pharmaceutically acceptable salts or solvates thereof:

• in which:
• Ar1 is dichlorophenyl or thienyl substituted by one or two chlorine atoms;
• A is a pyrimidine, pyridazine or 1,2,4-triazine ring, each of which can be optionally substituted by one or more groups selected from hydroxyl, halogen, cyano, C1-6alkyl, C1-6alkoxy or C3-6cycloalkyl where in each case the alkyl group may be substituted with 1-3 fluorine atoms, a cyano group or a hydroxy group;
• R1 is C1-6alkyl or C3-6cycloalkyl each of which can be optionally substituted with 1-3 fluorine atoms or a cyano group or R1 is C3-6alkenyl or C3-6alkynyl or C1-6alkyl-R2
• R2 is an aryl group or a 5-7 membered heteroaromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur each of which can be optionally substituted by 1-3 groups selected from halogen, C1-6alkyl, C1-6alkoxy, ═O, ═S, CN or (CH2)nOH where n is 1 or 2.