Methods for treating hepatitis C

A pharmaceutical composition comprising:

• (i) a compound of formula I
• wherein:
• X is:
• -a nitro group;
• -a cyano group;
• -a —CORa group, where Ra is:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or a halogen, or
• -a dialkyl-amino;
• -a —COORx group, where Rx is a C1 to C6 alkyl;
• -a formyl group;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• or
• -a 5 or 6-membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more halogen(s), or
• -a 5 to 6 membered heteroaryl;
• Y is:
• -a haloalkyl;
• -a halogen;
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a benzofuran;
• -a benzothiophene;
• -a dibenzofuran;
• -a dibenzothiophene;
• -a benzothiazole;
• -a naphthalene;
• -an indole, optionally substituted on the nitrogen with a C1 to C6 alkyl;
• where Rb is a hydrogen or a C1 to C6 alkyl, and n is 0 or 1;
• where Rc is a hydrogen, a —CONHRx, where Rx is as defined above, or an —SO2Rx, where Rx is as defined above;
• or
• where Rd is a C1 to C6 alkyl or a C6 to C8 aryl;
• -a —NHCORe group, where Re is:
• -a C1 to C6 alkyl;
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -an alkoxy,
• -a cyano group,
• -a nitro group, or
• -a halogen;
• -a —NHCOORx group, where Rx is as defined above;
• -a —CH2O—Rf group, where Rf is a C6 to C8 aryl;
• -a —NRgRh group, where Rg is a C1 to C6 alkyl or a hydrogen and Rh is a C6 to C8 aryl optionally substituted with an alkoxy;
• -a C1 to C6 alkyl;
• -a 5 or 6 membered heteroaryl, optionally substituted with:
• -a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a C6 to C8 aryl, optionally substituted with —COORx, where Rx is as defined above, or
• -an amino group;
• -a 5 or 6 membered heterocycle optionally substituted with:
• -a —COORx group, where Rx is as defined above, or
• -a —NHCOORx group, where Rx is as defined above;
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy, optionally substituted with:
• -an alkoxy,
• -a hydroxy,
• -one or more halogen(s),
• -a 5 or 6 membered heterocycle, optionally substituted with:
• -a C1 to C6 alkyl, or
• -a hydroxy,
• -an amino group optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NRiSO2Rx group, where Rx is as defined above and Ri is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRjCORk group, where Rk is:
• -a C1 to C6 alkyl,
• -a hydrogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• and Rj is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —N═N+═N− group, or
• -a —CORl, where Rl is a 5 or 6 membered heterocycle optionally substituted with a hydroxy,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a nitro group,
• -a C1 to C6 alkyl group, optionally substituted with:
• -a —NHSO2Rx group, where Rx is as defined above, or
• -a —NRxSO2Rx group, where Rx is as defined above,
• -a haloalkoxy,
• -a halogen,
• -a hydroxy,
• -a —COORx group, where Rx is as defined above,
• -a —CORm group, where Rm is:
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the C1 to C6 alkyls are optionally substituted with:
• -a hydroxy
• -a 5 or 6 membered heterocycle,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -an alkoxy,
• -a 3 to 7 membered heterocycle, optionally substituted with a C1 to C6 alkyl, optionally substituted with a dialkyl-amino,
• -a —NHRn group, where Rn is:
• -a —CH2CONH2, or
• -a C6 to C8 aryl optionally substituted with:
• -an alkyl,
• -one or more halogen(s),
• -a nitro group, or
• -one or more alkoxy(s),
• -a —NRoCORp group, where Rp is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -an alkoxy, or
• -a C6 to C8 aryl,
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with a halogen,
• -a 5 or 6 membered heteroaryl optionally substituted with one or more C1 to C6 alkyl(s),
• -a hydrogen,
• and where Ro is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRqCONRqRr group, where Rq is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• and where Rr is:
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a —ORs group, where Rs is a C6 to C8 aryl, or
• -a —COORx group, where Rx is as defined above,
• -a C1 to C6 alkyl optionally substituted with one or more of the following:
• -a halogen,
• -an alkylene,
• -a C6 to C8 aryl, and/or
• -a —COORx group, where Rx is as defined above,
• -a —COORx group, where Rx is as defined above,
• -a —NRtCOORu group, where Ru is:
• -a C1 to C12 alkyl, optionally substituted with:
• -a C6 to C8 aryl optionally substituted with a C1 to C6 alkyl or an alkoxy,
• -an alkylene,
• -an alkoxy,
• -an alkyne,
• -a halogen, or
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -a C1 to C6 alkyl, or
• -a 5 or 6 membered heterocycle,
• and Rt is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRvSO2Rw group, where Rv is:
• -a hydrogen,
• -a —CORx, where Rx is as defined above, or
• -a C1 to C6 alkyl, optionally substituted with:
• -a halogen,
• -a —CORx group, where Rx is as defined above,
• -a —OCORx group, where Rx is as defined above,
• -a hydroxy, or
• -an alkoxy,
• and where Rw is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -a haloalkyl,
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle,
• -a C2 to C6 alkylene,
• -an alkyl- or dialkyl-amino optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle, or
• -a 5 or 6 membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a 5 or 6 membered heterocycle, or
• optionally substituted with a C1 to C6 alkyl, where Ry is a C1 to C6 alkyl or hydrogen,
• where Rz is hydrogen or a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a —SRx group, where Rx is as defined above,
• -a —SO2Raa group, where Raa is:
• -a C1 to C6 alkyl,
• -an amino group,
• -an alkyl- or dialkyl-amino group optionally substituted with a hydroxy or a —COORx group, where Rx is as defined above,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, and/or
• -a —NHRbb group, where Rbb is:
• -a —C(═S)NH2 group, or
• -a —PO(ORx)2 group, where Rx is as defined above;
• -a *Rcc group, where Rcc is:
• -a naphthalene,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy,
• -a hydroxy,
• -a halogen,
• -a C1 to C6 alkyl, optionally substituted with a cyano group,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NHPORxRx, where Rx is as defined above,
• -a —NReeCONRffRff group, where Ree is a hydrogen or a C1 to C6 alkyl, optionally substituted with a halogen, and Rff is:
• -a hydrogen,
• -a haloalkyl,
• -a haloalkoxy,
• -a C1 to C6 alkyl, or
• -a —CORx, where Rx is as defined above,
• -a —NRggCORhh group, where Rhh is:
• -a hydrogen,
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the alkyls are optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle,
• -a 5 or 6 membered heteroaryl,
• and Rgg is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl,
• -5 or 6 membered heterocycle groups,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), and/or
• -a —NRiiSO2Rx group, where Rx is as defined above, and Rii is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy,
• -a —CORx group, where Rx is as defined above;
• Z is:
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -one or more halogen(s), or
• -a C6 to C8 aryl;
• -a C2 to C6 alkylene;
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more C1 to C6 alkyl(s);
• -a —COORx group, where Rx is as defined above;
• or
• R is a hydrogen, a halogen or an alkoxy;
• R1 is:
• -a hydrogen;
• -a hydroxy;
• -a halogen;
• -a haloalkyl;
• -a nitro group;
• -a 5 or 6 membered heteroaryl;
• -a 5 or 6 membered heterocycle;
• -an alkoxy optionally substituted with:
• -one or more halogen(s),
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• -a —CORx group, where Rx is as defined above;
• -a C1 to C6 alkyl optionally substituted with a dialkyl-amino or a 5 or 6 membered heterocycle;
• or
• R1 joins together with R2 to form:
• R2 is:
• -a nitro group;
• -a hydrogen;
• -a halogen;
• -a hydroxy group;
• -a C1 to C6 alkyl group, optionally substituted with one or more halogen(s);
• -an amino group;
• -an alkoxy group optionally substituted with:
• -one or more halogen(s),
• -an —OCORx group, where Rx is as defined above,
• -a dialkyl-amino optionally substituted with an alkoxy,
• -a 5 or 6 membered heterocycle group optionally substituted with a C1 to C6 alkyl,
• -a 5 or 6 membered heteroaryl group, or
• -a C6 to C8 aryl group;
• -a —COORx group, where Rx is as defined above;
• -a haloalkyl;
• -an amide group optionally substituted with:
• -a hydroxy group, or
• -a C6 to C8 aryl;
• -a 5 or 6 membered heteroaryl;
• -a —OCORx group, where Rx is as defined above;
• -a —NHCORjj group, where Rjj is:
• -an alkoxy, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a —ORkk group, where Rkk is a 5 to 6 membered heteroaryl;
• -a —NHSO2Rx group, where Rx is as defined above;
• or
• R2 joins together with R1 to form:
• R3 is:
• -a hydrogen;
• or
• —CH2OCORx, and Rx is as defined above;
• provided that when X is phenyl, hydroxyphenyl or pyridyl, Y is alkyl, R is hydrogen, R1 is hydrogen or hydroxy, R2 is hydrogen or hydroxy, and R3 is hydrogen,
• then Z is:
• -a C1 to C6 alkyl substituted with:
• -an alkoxy,
• -one or more halogen(s), or
• -a C6 to C8 aryl;
• -a C2 to C6 alkylene;
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more C1 to C6 alkyl(s);
• -a —COORx group, where Rx is as defined above;
• or
• or
• or one or more pharmaceutically acceptable salt(s) thereof;
• and
• (ii) one or more pharmaceutically acceptable excipient(s).

A method for treating an infection by a virus in a subject in need thereof, wherein the virus contains an internal ribosome entry site (IRES), comprising administering to the subject one or more compound(s) of formula I or a pharmaceutical composition comprising one or more compound(s) of formula I

• wherein:
• X is:
• -a nitro group;
• -a cyano group;
• -a —CORa group, where Ra is:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or a halogen, or
• -a dialkyl-amino;
• -a —COORx group, where Rx is a C1 to C6 alkyl;
• -a formyl group;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• or
• -a 5 or 6-membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more halogen(s), or
• -a 5 to 6 membered heteroaryl;
• Y is:
• -a haloalkyl;
• -a halogen;
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a benzofuran;
• -a benzothiophene;
• -a dibenzofuran;
• -a dibenzothiophene;
• -a benzothiazole;
• -a naphthalene;
• -an indole, optionally substituted on the nitrogen with a C1 to C6 alkyl;
• where Rb is a hydrogen or a C1 to C6 alkyl, and n is 0 or 1;
• where Rc is a hydrogen, a —CONHRx, where Rx is as defined above, or an —SO2Rx, where Rx is as defined above;
• or
• where Rd is a C1 to C6 alkyl or a C6 to C8 aryl;
• -a —NHCORe group, where Re is:
• -a C1 to C6 alkyl;
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -an alkoxy,
• -a cyano group,
• -a nitro group, or
• -a halogen;
• -a —NHCOORx group, where Rx is as defined above;
• -a —CH2O—Rf group, where Rf is a C6 to C8 aryl;
• -a —NRgRh group, where Rg is a C1 to C6 alkyl or a hydrogen and Rh is a C6 to C8 aryl optionally substituted with an alkoxy;
• -a C1 to C6 alkyl;
• -a 5 or 6 membered heteroaryl, optionally substituted with:
• -a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a C6 to C8 aryl, optionally substituted with —COORx, where Rx is as defined above, or
• -an amino group;
• -a 5 or 6 membered heterocycle optionally substituted with:
• -a —COORx group, where Rx is as defined above, or
• -a —NHCOORx group, where Rx is as defined above;
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy, optionally substituted with:
• -an alkoxy,
• -a hydroxy,
• -one or more halogen(s),
• -a 5 or 6 membered heterocycle, optionally substituted with:
• -a C1 to C6 alkyl, or
• -a hydroxy,
• -an amino group optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NRiSO2Rx group, where Rx is as defined above and Ri is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRjCORk group, where Rk is:
• -a C1 to C6 alkyl,
• -a hydrogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• and Rj is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —N═N+═N− group, or
• -a —CORl, where Rl is a 5 or 6 membered heterocycle optionally substituted with a hydroxy,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a nitro group,
• -a C1 to C6 alkyl group, optionally substituted with:
• -a —NHSO2Rx group, where Rx is as defined above, or
• -a —NRxSO2Rx group, where Rx is as defined above,
• -a haloalkoxy,
• -a halogen,
• -a hydroxy,
• -a —COORx group, where Rx is as defined above,
• -a —CORm group, where Rm is:
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the one or more C1 to C6 alkyl(s) is/are optionally substituted with:
• -a hydroxy
• -a 5 or 6 membered heterocycle,
• -an amino optionally substituted with one or more C1 to C6 alkyls, and/or
• -an alkoxy,
• -a 3 to 7 membered heterocycle, optionally substituted with a C1 to C6 alkyl, optionally substituted with a dialkyl-amino,
• -a —NHRn group, where Rn is:
• -a —CH2CONH2, or
• -a C6 to C8 aryl optionally substituted with:
• -an alkyl,
• -one or more halogen(s),
• -a nitro group, or
• -one or more alkoxy(s),
• -a —NRoCORp group, where Rp is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -an alkoxy, or
• -a C6 to C8 aryl,
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with a halogen,
• -a 5 or 6 membered heteroaryl optionally substituted with one or more C1 to C6 alkyl(s),
• -a hydrogen,
• and where Ro is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRqCONRqRr group, where Rq is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• and where Rr is:
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a —ORs group, where Rs is a C6 to C8 aryl, or
• -a —COORx group, where Rx is as defined above,
• -a C1 to C6 alkyl optionally substituted with one or more of the following:
• -a halogen,
• -an alkylene,
• -a C6 to C8 aryl, and/or
• -a —COORx group, where Rx is as defined above,
• -a —COORx group, where Rx is as defined above,
• -a —NRtCOORu group, where Ru is:
• -a C1 to C12 alkyl, optionally substituted with:
• -a C6 to C8 aryl optionally substituted with a C1 to C6 alkyl or an alkoxy,
• -an alkylene,
• -an alkoxy,
• -an alkyne,
• -a halogen, or
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -a C1 to C6 alkyl, or
• -a 5 or 6 membered heterocycle,
• and Rt is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRvSO2Rw group, where Rv is:
• -a hydrogen,
• -a —CORx, where Rx is as defined above, or
• -a C1 to C6 alkyl, optionally substituted with:
• -a halogen,
• -a —CORx group, where Rx is as defined above,
• -a —OCORx group, where Rx is as defined above,
• -a hydroxy, or
• -an alkoxy,
• and where Rw is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -a haloalkyl,
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle,
• -a C2 to C6 alkylene,
• -an alkyl- or dialkyl-amino optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle, or
• -a 5 or 6 membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a 5 or 6 membered heterocycle, or
• optionally substituted with a C1 to C6 alkyl, where Ry is a C1 to C6 alkyl or hydrogen,
• where Rz is hydrogen or a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a —SRx group, where Rx is as defined above,
• -a —SO2Raa group, where Raa is:
• -a C1 to C6 alkyl,
• -an amino group,
• -an alkyl- or dialkyl-amino group optionally substituted with a hydroxy or a —COORx group, where Rx is as defined above,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, and/or
• -a —NHRbb group, where Rbb is:
• -a —C(═S)NH2 group, or
• -a —PO(ORx)2 group, where Rx is as defined above;
• -a *Rcc group, where Rcc is:
• -a naphthalene,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy,
• -a hydroxy,
• -a halogen,
• -a C1 to C6 alkyl, optionally substituted with a cyano group,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NHPORxRx, where Rx is as defined above,
• -a —NReeCONRffRff group, where Ree is a hydrogen or a C1 to C6 alkyl, optionally substituted with a halogen, and Rff is:
• -a hydrogen,
• -a haloalkyl,
• -a haloalkoxy,
• -a C1 to C6 alkyl, or
• -a —CORx, where Rx is as defined above,
• -a —NRggCORhh group, where Rhh is:
• -a hydrogen,
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the alkyls are optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle,
• -a 5 or 6 membered heteroaryl,
• and Rgg is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl,
• -5 or 6 membered heterocycle groups,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), and/or
• -a —NRiiSO2Rx group, where Rx is as defined above, and Rii is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy,
• -a —CORx group, where Rx is as defined above;
• Z is:
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -one or more halogen(s), or
• -a C6 to C8 aryl;
• -a C2 to C6 alkylene;
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more C1 to C6 alkyl(s);
• -a —COORx group, where Rx is as defined above;
• or
• R is a hydrogen, a halogen or an alkoxy;
• R1 is:
• -a hydrogen;
• -a hydroxy;
• -a halogen;
• -a haloalkyl;
• -a nitro group;
• -a 5 or 6 membered heteroaryl;
• -a 5 or 6 membered heterocycle;
• -an alkoxy optionally substituted with:
• -one or more halogen(s),
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• -a —CORx group, where Rx is as defined above;
• -a C1 to C6 alkyl optionally substituted with a dialkyl-amino or a 5 or 6 membered heterocycle;
• or
• R1 joins together with R2 to form:
• R2 is:
• -a nitro group;
• -a hydrogen;
• -a halogen;
• -a hydroxy group;
• -a C1 to C6 alkyl group, optionally substituted with one or more halogen(s);
• -an amino group;
• -an alkoxy group optionally substituted with:
• -one or more halogen(s),
• -an —OCORx group, where Rx is as defined above,
• -a dialkyl-amino optionally substituted with an alkoxy,
• -a 5 or 6 membered heterocycle group optionally substituted with a C1 to C6 alkyl,
• -a 5 or 6 membered heteroaryl group, or
• -a C6 to C8 aryl group;
• -a —COORx group, where Rx is as defined above;
• -a haloalkyl;
• -an amide group optionally substituted with:
• -a hydroxy group, or
• -a C6 to C8 aryl;
• -a 5 or 6 membered heteroaryl;
• -a —OCORx group, where Rx is as defined above;
• -a —NHCORjj group, where Rjj is:
• -an alkoxy, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a —ORkk group, where Rkk is a 5 to 6 membered heteroaryl;
• -a —NHSO2Rx group, where Rx is as defined above;
• or
• R2 joins together with R1 to form:
• R3 is:
• -a hydrogen;
• or
• —CH2OCORx, and Rx is as defined above;
• or
• one or more pharmaceutically acceptable salt(s) thereof.

A method for treating a Hepatitis C viral (HCV) infection in a subject in need thereof, comprising administering to the subject one or more compound(s) of formula I or a pharmaceutical composition comprising one or more compound(s) of formula I

• wherein:
• X is:
• -a nitro group;
• -a cyano group;
• -a —CORa group, where Ra is:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or a halogen, or
• -a dialkyl-amino;
• -a —COORx group, where Rx is a C1 to C6 alkyl;
• -a formyl group;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• or
• -a 5 or 6-membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more halogen(s), or
• -a 5 to 6 membered heteroaryl;
• Y is:
• -a haloalkyl;
• -a halogen;
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a benzofuran;
• -a benzothiophene;
• -a dibenzofuran;
• -a dibenzothiophene;
• -a benzothiazole;
• -a naphthalene;
• -an indole, optionally substituted on the nitrogen with a C1 to C6 alkyl;
• where Rb is a hydrogen or a C1 to C6 alkyl, and n is 0 or 1;
• where Rc is a hydrogen, a —CONHRx, where Rx is as defined above, or an —SO2Rx, where Rx is as defined above;
• or
• where Rd is a C1 to C6 alkyl or a C6 to C8 aryl;
• -a —NHCORe group, where Re is:
• -a C1 to C6 alkyl;
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -an alkoxy,
• -a cyano group,
• -a nitro group, or
• -a halogen;
• -a —NHCOORx group, where Rx is as defined above;
• -a —CH2O—Rf group, where Rf is a C6 to C8 aryl;
• -a —NRgRh group, where Rg is a C1 to C6 alkyl or a hydrogen and Rh is a C6 to C8 aryl optionally substituted with an alkoxy;
• -a C1 to C6 alkyl;
• -a 5 or 6 membered heteroaryl, optionally substituted with:
• -a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a C6 to C8 aryl, optionally substituted with —COORx, where Rx is as defined above, or
• -an amino group;
• -a 5 or 6 membered heterocycle optionally substituted with:
• -a —COORx group, where Rx is as defined above, or
• -a —NHCOORx group, where Rx is as defined above;
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy, optionally substituted with:
• -an alkoxy,
• -a hydroxy,
• -one or more halogen(s),
• -a 5 or 6 membered heterocycle, optionally substituted with:
• -a C1 to C6 alkyl, or
• -a hydroxy,
• -an amino group optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NRiSO2Rx group, where Rx is as defined above and Ri is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRjCORk group, where Rk is:
• -a C1 to C6 alkyl,
• -a hydrogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• and Rj is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —N═N+═N− group, or
• -a —CORl, where Rl is a 5 or 6 membered heterocycle optionally substituted with a hydroxy,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a nitro group,
• -a C1 to C6 alkyl group, optionally substituted with:
• -a —NHSO2Rx group, where Rx is as defined above, or
• -a —NRxSO2Rx group, where Rx is as defined above,
• -a haloalkoxy,
• -a halogen,
• -a hydroxy,
• -a —COORx group, where Rx is as defined above,
• -a —CORm group, where Rm is:
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the one or more C1 to C6 alkyl(s) is/are optionally substituted with:
• -a hydroxy
• -a 5 or 6 membered heterocycle,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -an alkoxy,
• -a 3 to 7 membered heterocycle, optionally substituted with a C1 to C6 alkyl, optionally substituted with a dialkyl-amino,
• -a —NHRn group, where Rn is:
• -a —CH2CONH2, or
• -a C6 to C8 aryl optionally substituted with:
• -an alkyl,
• -one or more halogen(s),
• -a nitro group, or
• -one or more alkoxy(s),
• -a —NRoCORp group, where Rp is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -an alkoxy, or
• -a C6 to C8 aryl,
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with a halogen,
• -a 5 or 6 membered heteroaryl optionally substituted with one or more C1 to C6 alkyl(s),
• -a hydrogen,
• and where Ro is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRqCONRqRr group, where Rq is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• and where Rr is:
• -a C6 to C8 aryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a —ORs group, where Rs is a C6 to C8 aryl, or
• -a —COORx group, where Rx is as defined above,
• -a C1 to C6 alkyl optionally substituted with one or more of the following:
• -a halogen,
• -an alkylene,
• -a C6 to C8 aryl, and/or
• -a —COORx group, where Rx is as defined above,
• -a —COORx group, where Rx is as defined above,
• -a —NRtCOORu group, where Ru is:
• -a C1 to C12 alkyl, optionally substituted with:
• -a C6 to C8 aryl optionally substituted with a C1 to C6 alkyl or an alkoxy,
• -an alkylene,
• -an alkoxy,
• -an alkyne,
• -a halogen, or
• -a 5 or 6 membered heterocycle,
• -a C6 to C8 aryl, optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -a C1 to C6 alkyl, or
• -a 5 or 6 membered heterocycle,
• and Rt is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl, or
• -a haloalkoxy,
• -a —NRvSO2Rw group, where Rv is:
• -a hydrogen,
• -a —CORx, where Rx is as defined above, or
• -a C1 to C6 alkyl, optionally substituted with:
• -a halogen,
• -a —CORx group, where Rx is as defined above,
• -a —OCORx group, where Rx is as defined above,
• -a hydroxy, or
• -an alkoxy,
• and where Rw is:
• -a C1 to C6 alkyl optionally substituted with:
• -a halogen,
• -a haloalkyl,
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle,
• -a C2 to C6 alkylene,
• -an alkyl- or dialkyl-amino optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle, or
• -a 5 or 6 membered heteroaryl optionally substituted with:
• -a C1 to C6 alkyl,
• -a 5 or 6 membered heterocycle, or
• optionally substituted with a C1 to C6 alkyl, where Ry is a C1 to C6 alkyl or hydrogen,
• where Rz is hydrogen or a C1 to C6 alkyl, optionally substituted with a C6 to C8 aryl,
• -a —SRx group, where Rx is as defined above,
• -a —SO2Raa group, where Raa is:
• -a C1 to C6 alkyl,
• -an amino group,
• -an alkyl- or dialkyl-amino group optionally substituted with a hydroxy or a —COORx group, where Rx is as defined above,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, and/or
• -a —NHRbb group, where Rbb is:
• -a —C(═S)NH2 group, or
• -a —PO(ORx)2 group, where Rx is as defined above;
• -a *Rcc group, where Rcc is:
• -a naphthalene,
• -a 5 or 6 membered heteroaryl,
• -a C6 to C8 aryl, optionally substituted with one or more of the following:
• -an alkoxy,
• -a hydroxy,
• -a halogen,
• -a C1 to C6 alkyl, optionally substituted with a cyano group,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -a —NHPORxRx, where Rx is as defined above,
• -a —NReeCONRffRff group, where Ree is a hydrogen or a C1 to C6 alkyl, optionally substituted with a halogen, and Rff is:
• -a hydrogen,
• -a haloalkyl,
• -a haloalkoxy,
• -a C1 to C6 alkyl, or
• -a —CORx, where Rx is as defined above,
• -a —NRggCORhh group, where Rhh is:
• -a hydrogen,
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -a halogen, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s),
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), where the one or more C1 to C6 alkyl(s) is/are optionally substituted with a halogen,
• -a 5 or 6 membered heterocycle,
• -a 5 or 6 membered heteroaryl,
• and Rgg is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy, or
• -a —CORx group, where Rx is as defined above,
• -a haloalkyl,
• -5 or 6 membered heterocycle groups,
• -an amino optionally substituted with one or more C1 to C6 alkyl(s), and/or
• -a —NRiiSO2Rx group, where Rx is as defined above, and Rii is:
• -a hydrogen,
• -a C1 to C6 alkyl,
• -a haloalkyl,
• -a haloalkoxy,
• -a —CORx group, where Rx is as defined above;
• Z is:
• -a C1 to C6 alkyl optionally substituted with:
• -an alkoxy,
• -one or more halogen(s), or
• -a C6 to C8 aryl;
• -a C2 to C6 alkylene;
• -a C6 to C8 aryl optionally substituted with an alkoxy or one or more C1 to C6 alkyl(s);
• -a —COORx group, where Rx is as defined above;
• or
• R is a hydrogen, a halogen or an alkoxy;
• R1 is:
• -a hydrogen;
• -a hydroxy;
• -a halogen;
• -a haloalkyl;
• -a nitro group;
• -a 5 or 6 membered heteroaryl;
• -a 5 or 6 membered heterocycle;
• -an alkoxy optionally substituted with:
• -one or more halogen(s),
• -a C6 to C8 aryl, or
• -a 5 or 6 membered heterocycle;
• -a C6 to C8 aryl optionally substituted with an alkoxy;
• -a —CORx group, where Rx is as defined above;
• -a C1 to C6 alkyl optionally substituted with a dialkyl-amino or a 5 or 6 membered heterocycle;
• or
• R1 joins together with R2 to form:
• R2 is:
• -a nitro group;
• -a hydrogen;
• -a halogen;
• -a hydroxy group;
• -a C1 to C6 alkyl group, optionally substituted with one or more halogen(s);
• -an amino group;
• -an alkoxy group optionally substituted with:
• -one or more halogen(s),
• -an —OCORx group, where Rx is as defined above,
• -a dialkyl-amino optionally substituted with an alkoxy,
• -a 5 or 6 membered heterocycle group optionally substituted with a C1 to C6 alkyl,
• -a 5 or 6 membered heteroaryl group, or
• -a C6 to C8 aryl group;
• -a —COORx group, where Rx is as defined above;
• -a haloalkyl;
• -an amide group optionally substituted with:
• -a hydroxy group, or
• -a C6 to C8 aryl;
• -a 5 or 6 membered heteroaryl;
• -a —OCORx group, where Rx is as defined above;
• -a —NHCORjj group, where Rjj is:
• -an alkoxy, or
• -an amino optionally substituted with one or more C1 to C6 alkyl(s);
• -a —ORkk group, where Rkk is a 5 to 6 membered heteroaryl;
• -a —NHSO2Rx group, where Rx is as defined above;
• or
• R2 joins together with R1 to form:
• R3 is:
• -a hydrogen;
• or
• —CH2OCORx, and Rx is as defined above;
• or
• one or more pharmaceutically acceptable salt(s) thereof.