Pyridazinone compounds

A compound according to Formula I

• wherein
• R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or heterocyclyl, and Ring A is 5- or 6-membered aryl or heterocyclyl,
• wherein the above alkyl, aryl, cycloalkyl, or heterocyclyl moieties are optionally substituted by 1-3 substituents selected from
• alkanoyl,
• alkylamine,
• amino,
• aryl, cycloalkyl, heterocyclyl,
• C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, C1-C6 alkylamine, C1-C6 dialkylamine, C2-C6 alkenyl, or C2-C6 alkynyl, wherein each of which may be interrupted by one or more hetero atoms,
• carboxyl,
• cyano,
• halo,
• hydroxy,
• nitro,
• —N═N—NH2,
• —C(O)2—(C1-C6 alkyl), —C(O)2-(aryl), —C(O)2-(cycloalkyl), —C(O)2-(heterocyclyl), —O—(C1-C6 haloalkyl), —O—(C1-C6 alkyl)aryl, —O—(C1-C6 alkyl)cycloalkyl, —O—(C1-C6 alkyl)heterocyclyl, —O—(C1-C6 alkyl)amino, —O—(C1-C6 alkyl)alkylamino, —O—(C1-C6 alkyl)dialkylamino, —O—(C1-C6 alkyl)-C(O)OH, —O—(C1-C6 alkyl)-C(O)—O—(C1-C6 alkyl), —O—(C1-C6 alkyl)-C(O)NH2, —O—(C1-C6 alkyl)-C(O)NH—(C1-C6 alkyl), —O—(C1-C6 alkyl)-C(O)N—(C1-C6 alkyl)dialkyl, —O—(C1-C6 alkyl)-C(O)-heterocyclyl, —O-aryl, —O-heterocyclyl, —NHC(O)-(C1-C6 alkyl), —NHC(O)—(C1-C6 alkylene), —NHC(O)-(aryl), —NHC(O)-cycloalkyl), —NHC(O)-(heterocyclyl), —NHC(OH(C1-C6 alkyl)aryl, —NHC(O)—(C1-C6 alkyl)cycloalkyl, —NHC(O)—(C1-C6 alkyl)heterocyclyl, —NHC(O)—(C1-C6 alkyl)amino, —NHC(O)—(C1-C6 alkyl)alkylamine, —NHC(O)—(C1-C6 alkyl)dialkylamine, —NHC(O)—(C1-C6 alkyl)C(O)amino, —NHC(O)—(C1-C6 alkyl)C(O)alkylamine, —NHC(O)—(C1-C6alkyl)C(O)dialkylamine, —NHC(O)—(C1-C6 alkyl)N(H)—(C1-C6 alkyl)C(O)2—(C1-C6 alkyl), —NHC(O)—(C1-C6 alkyl)S(O)2(C1-C6 alkyl), —NHC(O)—(C1-C6 alkyl)-S-(heterocyclyl), —NHS(O)2—(C1-C6 alkyl), —NHS(O)2-(aryl), —NHS(O)2-(cycloalkyl), —NHS(O)2-(heterocyclyl), —NHS(O)(C1-C6 alkyl), —NHS(O)(aryl), —NHS(O)(cycloalkyl), —NHS(O)(heterocyclyl), —NHS(C1-C6 alkyl), —NHS(aryl), —NHS(cycloalkyl), —NH—S-(heterocyclyl),
• wherein each of the above substituents can be further optionally substituted by 1-5 substituents selected from
• amino,
• C1-C6 alkylamine, C1-C6 dialkylamine,
• C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkenyl, C1-C6 hydroxyl, and C1-C6
• hydroxyalkyl, each optionally substituted by halo,
• cyano, and
• nitro,
• or a pharmaceutically acceptable salt, hydrate, tautomer or stereoisomer thereof.