Antibacterial agents

A compound of formula (I)

• wherein:
• Z1 is N or CR1a;
• R1 and R1a are independently hydrogen;
• hydroxy;
• (C1-6)alkoxy unsubstituted or substituted by (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstitued or N-substituted by one or two (C1-6)alkyl, acyl, (C1-16)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• halogen;
• (C1-6)alkyl;
• (C1-6)alkylthio;
• trifluoromethyl;
• trifluoromethoxy;
• nitro;
• azido;
• cyano;
• acyl;
• acyloxy;
• acylthio;
• (C1-6)alkylsulphonyl;
• (C1-6)alkylsulphoxide;
• arylsulphonyl;
• arylsulphoxide;
• or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl or (C1-6)alkylsulphonyl groups;
• or R1 and R1a may together form ethylenedioxy;
• provided that when Z1 is CR1a then R1 is not H;
• R2 is H or halogen;
• provided that when Z1 is N, then R2 is H;
• R3 is hydrogen;
• halogen;
• hydroxy;
• cyano;
• CF3;
• nitro;
• azido;
• acyl;
• aryl;
• heteroaryl;
• CO2H;
• acyoxy;
• acylthio;
• (C1-6)alkyl unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C1-6)alkoxy unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C3-7)cycloalkyl;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• (C1-6)alkylthio;
• trifluoromethoxy;
• (C1-6)alkylsulphonyl;
• (C1-6)alkylsulphoxide;
• arylsulphonyl;
• or arylsulphoxide;
• or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl or (C1-6)alkylsulphonyl groups;
• w1 is N, C, or CR4;
• w2 is C═O, CR4, or CR4R5;
• w3 is C═O or CR4R5;
• w4 is N or CR4;
• w5 is C═O or CR4R5;
• w6 is C═O, CR4, or CR4R5;
• or, one of W2, W3, W5 and W6 is CR4R5CR4R5 and the others are defined as above;
• wherein each R4 and R5 is independently hydrogen;
• halogen;
• hydroxy;
• cyano;
• CF3;
• nitro;
• azido;
• acyl;
• aryl;
• heteroaryl;
• CO2H;
• acyoxy;
• acylthio;
• (C1-6)alkyl unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstitued unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C1-6)alkoxy unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C3-7)cycloalkyl;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• (C1-6)alkylthio;
• trifluoromethoxy;
• (C1-6)alkylsulphonyl;
• (C1-6)alkylsulphoxide;
• arylsulphonyl;
• or arylsulphoxide;
• or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl or (C1-6)alkylsulphonyl groups;
• or two R5 groups are joined together to form bicycloheptane;
• A is CR6R7 or C(O);
• B is CR8R9 or C(O);
• wherein R6, R7, R8, and R9 are independently hydrogen;
• halogen;
• hydroxy;
• cyano;
• CF3;
• nitro;
• azido;
• acyl;
• aryl;
• heteroaryl;
• CO2H;
• acyoxy;
• acylthio;
• (C1-6)alkyl unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C1-6)alkoxy unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, guanidino or amidino any of which is unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, CONH2, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy or (C1-6)alkylsulphonyloxy;
• (C3-7)cycloalkyl;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• (C1-6)alkylthio;
• trifluoromethoxy;
• (C1-6)alkylsulphonyl;
• (C1-6)alkylsulphoxide;
• arylsulphonyl;
• or arylsulphoxide;
• or an amino, piperidyl, guanidino or amidino group unsubstituted or N-substituted by one or two (C1-6)alkyl, acyl or (C1-16)alkylsulphonyl groups;
• R10 is hydrogen;
• aryl;
• heteroaryl;
• (C1-6)alkyl unsubstituted or substituted by one or two (C1-6)alkoxy, hydroxy, amino, piperidyl, piperazinyl, morpholino, guanidino, or amidino, any of which is unsubstituted or N-substituted by one or two aryl, heteroaryl, halogen, cyano, CF3, unsubstituted (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, arylsulphonyl, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy, or (C1-6)alkylsulphonyloxy, so long as provided that the substitution does not lead to an unstable compound;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• hydroxy-substituted(C1-6)alkyl;
• (C1-6)alkylcarbonyl;
• (C2-6)alkenylcarbonyl;
• (C1-6)alkoxycarbonyl;
• CO2H;
• or CF3;
• R11 is a group —U—R12 where R12 is a substituted or unsubstituted bicyclic carbocyclic or heterocyclic ring system (A):
• containing up to four heteroatoms in each ring in which
• at least one of rings (a) and (b) is aromatic;
• X1 is C or N when part of an aromatic ring or CR14 when part of a non aromatic ring;
• X2 is N, NR13, O, S(O)x, CO or CR14 when part of an aromatic or non-aromatic ring or may in addition be CR14R15 when part of a non aromatic ring;
• X3 and X5 are independently N or C;
• Y1 is a 0 to 4 atom linker group each atom of which is independently selected from N, NR13, O, S(O)x, CO and CR14 when part of an aromatic or non-aromatic ring or may additionally be CR14R15 when part of a non aromatic ring,
• Y2 is a 2 to 6 atom linker group, each atom of Y2 being independently selected from N, NR13, O, S(O)x, CO and CR14 when part of an aromatic or non-aromatic ring or may additionally be CR14R15 when part of a non aromatic ring;
• each of R14 and R15 is independently selected from:
• H;
• (C1-4)alkylthio;
• halo;
• (C1-4)alkyl;
• (C2-4)alkenyl;
• hydroxy;
• hydroxy(C1-4)alkyl;
• mercapto(C1-4)alkyl;
• (C1-4)alkoxy;
• trifluoromethoxy;
• nitro;
• cyano;
• carboxy;
• amino or aminocarbonyl unsubstituted or substituted by (C1-4)alkyl;
• each R13 is independently H;
• trifluoromethyl;
• (C1-4)alkyl unsubstituted or substituted by hydroxy, carboxy, (C1-4)alkoxy, (C1-6)alkylthio, halo or trifluoromethyl;
• (C2-4)alkenyl;
• or aminocarbonyl wherein the amino group is optionally substituted (C1-4)alkyl;
• each x is independently 0, 1 or 2;
• U is CO, SO2, CH2, or CR16R17;
• R16 and R17 are independently selected from H;
• aryl;
• heteroaryl;
• (C1-6)alkyl;
• (C1-6)alkyl substituted by (C1-6)alkoxy, hydroxy, amino, piperidyl, piperazinyl, morpholino, guanidino, or amidino, any of which is substituted or N-substituted by one or two H, aryl, heteroaryl, halogen, cyano, CF3, (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, arylsulphonyl, hydroxy, (C1-6)alkylthio, heterocyclylthio, heterocyclyloxy, arylthio, aryloxy, acylthio, acyloxy, or (C1-6)alkylsulphonyloxy, so as provided that the substitution does not lead to an unstable compound;
• (C1-6)alkoxy-substituted(C1-6)alkyl;
• hydroxy-substituted(C1-6)alkyl;
• amino-substituted(C1-6)alkyl, which is N-substituted by one or two (C1-6)alkyl, acyl, (C1-6)alkylsulphonyl, or arylsulphonyl;
• (C1-6)alkylcarbonyl;
• (C2-6)alkenylcarbonyl;
• (C1-6)alkoxycarbonyl;
• CO2H;
• or CF3;
• or
• a pharmaceutically acceptable salt thereof.