Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists

A compound having the formula:

• wherein
• T is
• where R6 is taken together with one of R7 and R8 to form a bridge of one to two carbon atoms, and the other of R7 and R8 is selected from hydrogen and R9;
• Ar and Ar1 are, independently of each other, aryl or heteroaryl, with the proviso that Ar and Ar1 are not simultaneously phenyl;
• F is alkylene, alkenylene, or a bond;
• E is selected from —C(═O)N(R10)—, —SO2N(R10)—, —N(R11)C(═O)N(R10)—, —N(R11)SO2N(R10)—, —N(R11)C(═S)N(R10)—, —N(R11)C(═O)—, —N(R11)SO2—, —N(R12)C(═O)CH(R13)—, and CH(R13)C(═O)N(R12)—, where:
• R10, R11, R12, and R13 are, independently of each other, hydrogen, alkyl, acyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(═O)-Z, where Z is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy;
• or alternatively, R12 and R13 may be taken together with the nitrogen and carbon atoms to which they are attached, respectively, to form a heterocyclyl or heteroaryl ring optionally substituted with up to two groups selected from R14;
• R3 and R4 are, independently of each other, hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, heteroalkyl, -(alkylene)-C(═O)-Z1, or -(alkylene)-C(O)2Z1, where Z1 is alkyl, haloalkyl, alkoxy, haloalkyloxy, hydroxy, amino, mono- or disubstituted amino, aryl, aralkyl, aryloxy, aralkyloxy, heteroaryl, heteroaryloxy, or heteroaralkyloxy;
• R5 is hydrogen or alkyl;
• Q is —C(═O)— or C1-2alkylene;
• R9 is attached to any available carbon atom of ring T and is selected from lower alkyl, hydroxy, lower alkoxy, halo, cyano, trifluoromethyl, trifluoromethoxy, or a lower alkyl substituted with one of hydroxy, lower alkoxy, halo, cyano, trifluoromethyl, or trifluoromethoxy;
• R14 is selected from lower alkyl, hydroxy, lower alkoxy, halo, cyano, trifluoromethyl, trifluoromethoxy, and a lower alkyl substituted with one of hydroxy, lower alkoxy, halo, cyano, trifluoromethyl, or trifluoromethoxy;
• m is 0 or 1;
• and
• n is 0 to 4;
• and
• or a pharmaceutically acceptable salt thereof.