Crystal of 1-methylcarbapenem compound
AssigneeSankyo Company, Limited
InventorsMakoto Michida, Yuki Nagao
Life of this patent
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Abstract
A 1-methylcarbapenem compound ethanolate of the formula (I-1) in the crystalline form that shows main peaks at interplanar spacings d=7.60, 6.69, 6.33, 6.14, 5.15, 4.58 and 4.48 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation and a 1-methylcarbapenem compound tetrahydrate of the formula (I-2) in the crystalline form that shows main peaks at interplanar spacings d=11.68, 8.79, 7.53, 6.57, 5.58, 5.37, 3.99 and 3.09 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation These compounds are useful for treating or preventing bacterial infections.
Claims30
A 1-methylcarbapenem compound ethanolate of the formula (I-1) in the crystalline form that shows main peaks at interplanar spacings d=7.60, 6.69, 6.33, 6.14, 5.15, 4.58 and 4.48 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation
A 1-methylcarbapenem compound tetrahydrate of the formula (I-2) in the crystalline form that shows main peaks at interplanar spacings d=11.68, 8.79, 7.53, 6.57, 5.58, 5.37, 3.99 and 3.09 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation
A 1-methylcarbapenem compound ethanolate trihydrate of the formula (I-3) in the crystalline form that shows main peaks at interplanar spacings d=6.65, 5.68, 4.86, 4.57 and 4.03 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation wherein the water content is 8 to 10% by weight
Dependencies are inferred from the claim text.