1-Adamantyl chalcones for the treatment of proliferative disorders

A compound of the formula:

• wherein:
• R1 is Ad- or Ad--(L1)n--, wherein n is 0 or 1, Ad is adamantyl, and L1 is a linking group selected from the group consisting of C1-6 alkylene, C1-6 cycloalkylene, and C1-6 arylene;
• R2 is phenyl optionally substituted by X;
• wherein X is straight chain or branched C1-6 alkyl, halo, amino, C1-6 alkyl amino, C1-6 dialkyl amino, pyrrolidinyl, piperadinyl, morpholinyl, piperazinyl, C1-6 alkoxy, C1-6 aralkoxyl, aryl, C1-6 aralkyl, nitro, cyano or a phosphorus containing group;
• and
• Y is independently H, C1-6 alkyl, aryl, or halo;
• or a pharmaceutically acceptable salt or derivative thereof.