Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels
AssigneeNederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
InventorWillem Nieuwenhuizen
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Abstract
The present invention is in the field of cholesterol and triglyceride-lowering methods and compositions. In particular, the present invention relates to the use of sphingolipids, more preferably phytosphingosine, sphingosine, sphinganine, ceramide, cerebroside and/or sphingomyelin for lowering the cholesterol and triglyceride levels in a subject and to the use of sphingolipids as a plasma and/or serum cholesterol and triglyceride lowering agent. The invention also encompasses methods of treatment of subjects suffering from high plasma cholesterol and triglyceride levels, as well as food items and supplements with increased sphingolipid levels.
Claims20
Use of a sphingolipid with the general formula (I):
- wherein
- Z is R3 or —CH(OH)—R3;
- A is sulphate, sulphonate, phosphate, phosphonate or —C(O)O—;
- R1 is H, hydroxyl, alditol, aldose, an alcohol, C1-C6 alkyl or amino acid;
- R2 is H or unsaturated or saturated (C1-C30) alkyl chain;
- R3 is unsaturated or saturated (C1-C30) alkyl chain;
- Q1 is a primary amine group (—NH2), secondary amine group (—NH—) or an amide group (—NH—CO—);
- and
- t is 0 or 1, or a precursor, a derivative or a pharmaceutically acceptable salt thereof,
- for the manufacture of a medicament for reducing cholesterol and triglyceride levels in a subject.
Use of a sphingolipid according to the general formula (II):
- wherein
- Z is R3 or CH(OH)—R3, and
- R3 is an unsaturated or saturated (C1-C30) alkyl chain, or a precursor, a derivative or a pharmaceutically acceptable salt thereof,
- for the manufacture of a medicament for reducing cholesterol and triglyceride levels in a subject.
Use of a sphingolipid according to the general formula (III):
- wherein
- Z is R3 or CH(OH)—R3, preferably R3;
- Q1 is a primary amine group (—NH2), a secondary amine group (—NH—) or an amide group (—NH—CO—);
- preferably an amide group, and
- R2 is H or unsaturated or saturated (C1-C30) alkyl chain;
- R3 is an unsaturated or saturated (C1-C30) alkyl chain, preferably an unsaturated (C1-C30) alkyl chain, or a precursor, a derivative or a pharmaceutically acceptable salt thereof,
- for the manufacture of a medicament for reducing cholesterol and triglyceride levels in a subject.
Method of lowering cholesterol and triglyceride levels in plasma and/or serum of healthy subjects comprising providing said subjects a diet with enhanced levels of a sphingolipid as defined in any one of claims 1-6, 13, or 14 or a precursor, a derivative or a pharmaceutically acceptable salt thereof.
A food item comprising an elevated amount of a sphingolipid according to any one of claims 1 to 6, 13, or 14.
A food supplement comprising an elevated amount of a sphingolipid according to any one of claims 1 to 6, 13, or 14.
Dependencies are inferred from the claim text.